Variations of the Lung Compliance During Extracorporeal Circulation and Post Operative Pulmonary Complications
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Thoracic Surgery
- Sponsor
- Centre Chirurgical Marie Lannelongue
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- pulmonary compliance during cardiac surgery
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
the decrease in thoracopulmonary compliance after cardiac surgery is well known . The investigators hypothesize that the major factor determining pulmonary outcome after cardiac surgery is the alteration of pulmonary compliance during cardiopulmonary bypass(CBP) and that this alteration is due to CBP itself through pulmonary blood emptying.
Detailed Description
compliance is the compliance calculate when thorax is closed, the pulmonary compliance is the compliance calculated when thorax is opened After operation chest X-ray are daily done and blood samples as needed. Were recorded death, time of extubation,duration of non invasive ventilation,of Intensive Care Unit stay and of total hospital stay, troponin peak, lactates, blood gases, ionogram and count.Variations of compliance is analyzed through one factor paired Anova or Wilcoxon paired test. Decrease of compliance and respiratory complications are analyzed through binomial logistic regression.
Investigators
Eligibility Criteria
Inclusion Criteria
- •scheduled for standard aortic
- •mitral or coronary surgery
Exclusion Criteria
- •emergency operation
- •no complete preoperative echocardiography
- •surgery needing multiple table position changes
- •unstable cardiac or respiratory condition
- •difficult patient needing multiple care and/or special attention
Outcomes
Primary Outcomes
pulmonary compliance during cardiac surgery
Time Frame: intraoperative
compliance is calculated by dividing tidal volume (ml) by the difference between plateau-inspiratory pressure (mmHg) and end-expiratory pressure (mmHg) before ,during and after CBP
Secondary Outcomes
- thoracopulmonary compliance during cardiac surgery(intraoperative)
- pulmonary complications including death after cardiac surgery(1 month)