eural Structure and Function in Tourette Syndrome: distinguishing neural structure and function in Tourette Syndrome from attention-deficit/hyperactivity disorder.

Withdrawn

Conditions: Tourette's and ADHD
ontwikkelingsstoornissen NEG

Registration Number: NL-OMON41025

Lead Sponsor: Donders Institute of Brain, Cognition and Behavior

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Withdrawn

Sex: Not specified

Target Recruitment: 60

Inclusion Criteria

(1) Aged 8 - 12 years at initial inclusion
(2) IQ > 70
(3) Ability to speak and comprehend the native language of the country in which the assessment takes place
(4) Caucasian descent
(5) Signed informed consent by parents or legal representative
(6) DSM-5 diagnosis of Tourette's Disorder or Persistent (chronic) Motor or Vocal tic Disorder (motor tics only) (APA, 2013).

Exclusion Criteria

(1) Intellectual disability (IQ < 70)
(2) Major physical illness of the cardiovascular, endocrine, pulmonal or the gastrointestinal system
(3) All contra indications for MRI assessment, such as the presence of metal objects in or around the body (pacemaker, dental braces)
(4) History of or present neurological disorder

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Structural, diffusion and functional (resting state and task specific) MRI<br /><br>images will be obtained (approx. 60mins). Two neuropsychological tasks will be<br /><br>performed in an fMRI environment (go/no-go and monetary reward anticipation)<br /><br>with another 4 tasks completed outside of the MRI environment (motor inhibition<br /><br>and cognitive flexibility, verbal working memory, motor speed, cognitive<br /><br>flexibility). Phenotyping will be done by semi-structured interview for the<br /><br>Yale Global Tic Severity Scale (YGTSS) and Children*s Yale-Brown Obsessive<br /><br>Compulsive Scale (CY-BOCS). ADHD symptoms will be assessed additionally by<br /><br>Conners questionnaire. </p><br>

Secondary Outcome Measures