Evaluation of Liver Stiffness After Tricuspid Valvular Repair Using Magnetic Resonance Elastography
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 发起方
- Mayo Clinic
- 主要终点
- Change in liver stiffness between preoperative and postoperative MR elastography (MRE)
研究概览
简要总结
The purpose of this study is to look at liver stiffness with a MRI sequence called Magnetic Resonance Elastography (MRE). The study will let the investigators know whether the subject's liver is normal or has increased stiffness. Increased liver stiffness often means there is chronic liver disease and fibrosis. Increased right heart pressure and congestive heart failure are considered risk factors for development of liver fibrosis. Liver fibrosis, if progressive, may lead to cirrhosis and its related complications. The increased liver stiffness may be due to a poorly functioning tricuspid valve. With this research, the investigators will be able to determine if the elevated stiffness of the liver returns to normal after the surgeon performs a repair or replacement of the tricuspid valve.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Health Services Research
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 100 Years(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
研究组 & 干预措施
Tricuspid Valvular Repair Patients
Subjects will receive an MRI sequence called Magnetic Resonance Elastography (MRE) within 1 month preoperatively and as close to 6 months postoperatively as reasonably achievable.
干预措施: MRI (Device)
结局指标
主要结局
Change in liver stiffness between preoperative and postoperative MR elastography (MRE)
时间窗: baseline, approximately 6 months postoperatively
Increased liver stiffness often means there is chronic liver disease and fibrosis.
Change in tricuspid valve regurgitation measured by echocardiography
时间窗: baseline, approximately 6 months postoperatively
Increased liver stiffness may be due to a poorly functioning tricuspid valve.
次要结局
- Change in Subject Functional Capacity(baseline, approximately 6 months postoperatively)
研究者
Michael L Wells
Principal Investigator
Mayo Clinic
