The Exploration of the Effect of Mukbang on Functional Connectivity of Related Brain Regions in Children With Cancer Hospitalized for Radiotherapy and Chemotherapy Based on fMRI
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 44
- 试验地点
- 1
- 主要终点
- The pictures of activated functional areas of the brain
研究概览
简要总结
This study aims to use the intervention study method to extract and verify the effective ingredients in Mukbang that promote appetite and eating in children with tumor during radiotherapy and chemotherapy, and to analyze and explore their potential mechanisms of action based on functional magnetic resonance imaging.
详细描述
Cancer has a high incidence among children and adolescents worldwide. In October 2020, the World Health Organization (WHO) released an overview of the Global Action on Childhood Cancer which showed that more than 400,000 children under the age of 19 were diagnosed with cancer worldwide every year. With the development and progress of diagnosis and treatment technology, the health outcome of children with cancer has been greatly improved.
However, the side effects and complications associated with cancer and its treatment can seriously affect the appetite and food intake of children with cancer, resulting in malnutrition and a low quality of life. Therefore, it is very important to effectively improve the appetite of children with cancer during treatment.
Clinical methods to improve the appetite of cancer patients mainly include drugs, diet or nutrition intervention, traditional Chinese medicine and acupuncture, but each intervention has its own advantages and disadvantages which makes the clinical application effect difficult to evaluate, in urgent need of more effective solutions to solve this problem.
Mukbang has shown great potential in helping children with cancer to improve their appetite and food consumption, finally promote nutritional health. Mukbang is a method independently chosen by hospitalized cancer children with radiotherapy and chemotherapy to help promote appetite, which has a natural high acceptance. What's more, the features of Mukbang, such as high-quality and clear pictures, relaxed atmosphere created by the video makers, sounds while eating, and attractive images of food, may promote viewers' appetite and increase their intake imperceptibly.
In addition to that, watching Mukbang while eating can also provide a pleasant eating experience for children with cancer, and the interaction with the Mukbang anchor can also alleviate the loneliness of children who live in hospital for such a long time, so as to enhance the children's taste experience, relieve the negative emotions of loneliness and depression and promote their appetite and interest in food under the condition of ensuring a healthy diet.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 10 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •children with cancer aged between 10 to 18 years old;
- •diagnosed with any tumor or cancer other than brain tumor before the age of 18;
- •having received or are receiving inpatient treatment;
- •both the patient and the guardian can communicate in Chinese;
- •children with moderate or higher symptoms of decreased appetite were screened for the Therapy-Related Symptom Checklist for Children.
排除标准
- •a diagnosis of a serious disease other than a tumor, especially a brain disease such as epilepsy and organic psychosis, was identified from the case;
- •unable to complete communication due to serious mental or physical illness, such as cognitive impairment or unclear consciousness;
- •children with eye or ear dysfunction that prevents them from watching and listening to videos;
- •with braces, cardiac pacemakers and other items with iron magnetism that cannot be removed from the body;
- •people who suffer from claustrophobia, ADHD, and other problems of staying quiet in confined spaces for long periods of time.
结局指标
主要结局
The pictures of activated functional areas of the brain
时间窗: Baseline
The outcome can be collected using the Siemens 3T Prisma functional Magnetic Resonance Imaging machine with an Inspur data processing system. The pictures reflect the brain functional areas which can be activated by watching Mukbang.
次要结局
- Cancer Appetite and Symptom Questionnaire, CASQ(Change from baseline appetite at 1 hour intervention)
- The number of increased salivation and perceived appetite(Change from baseline salivation and perceived appetite during 1 hour fMRI scanning)
研究者
Wei XIA, PhD
Associate Professor
Sun Yat-sen University