Troponin T in Chronic Obstructive Pulmonary Disease (COPD) Patients After Physical Exercise
Not Applicable
Completed
- Conditions
- COPDMyocardial Diseases
- Interventions
- Device: Treadmill exercise test
- Registration Number
- NCT02721693
- Lead Sponsor
- LHL Helse
- Brief Summary
The primary purpose of the study is to investigate if physical exercise is associated with myocardial damage, expressed by elevated troponin T, in patients with COPD.
- Detailed Description
Patients with COPD will perform a cardiopulmonary exercise test (CPET) on treadmill until exhaustion, 8-12 minutes. Venous blood will be drawn before exercise test and 15 minutes, 3 hours and 24 hours after test for analysis of high sensitive Cardiac troponin T (hs-cTnT). The investigators will also measure arterial bloodgas, oxygen uptake, carbon dioxide consumption, ventilation, blood pressure, ECG, heart rate and ask for dyspnea-score.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
- COPD
- GOLD 2-4
- BODE-index ≥ 2
- Referred by physician to a CPET
Exclusion Criteria
- Other serious pulmonary diseases (e.g. cancer, sarcoidosis, restrictive pulmonary diseases)
- Chronic heart disease with unstable angina or myocardial infarction ≤ 3 months prior to inclusion
- Percutaneous coronary intervention (PCI)
- Hypertension that is not controlled
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Treadmill exercise test Treadmill exercise test Patients are subjected to an incremental Cardiopulmonary Exercise Test to exhaustion
- Primary Outcome Measures
Name Time Method Troponin T concentration 3 h 3 h
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
LHL-klinikkene
🇳🇴Hakadal, Akershus, Norway