Study about the efficacy of metformin to immune function in healthy volunteers.
- Conditions
- healthy volunteers
- Registration Number
- JPRN-UMIN000014337
- Lead Sponsor
- Okayama University Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up continuing
- Sex
- All
- Target Recruitment
- 20
Not provided
1. Subjects who have symptoms which are judged to require follow-up or treatment. 2. Subjects who have previous medical history of hepatic disease, renal disease, cardiovascular disease, endocrine disease, gastrointestinal disease, respiratory disease, blood disorders and malignancy. 3. Subjects who have previous medical history of lactic acidosis. 4. Subjects who are allergic to medicines. 5. Subjects who need to take other medicines from 7 days before the study to the end of it. 6. Subjects who have drinking habit. 7. Subjects who drink caffeine-containing beverage in daily average of 1.8 L or more (coffee, tea, green tea, cola, health drink, etc.) 8. Subjects who smoke 2 packs or more in daily average. 9. Subjects who have been enrolled in the other clinical trials within last 4 months before the administration of metformin and administered any investigational new drugs. 10. Subjects who have made a blood donation prior to the administration of metformin. 11. Subjects who have been shown any problems at health examination. 12. Pregnant wouman 13. Other subjects who are judged to be ineligible in this trial by the investigator.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Ability to produce cytokines (IL-2, TNF alpha, IFN gamma) and differentiation (memory, helper etc.) in peripheral blood T cells.
- Secondary Outcome Measures
Name Time Method