Neurofunctional Specificities in Predictive Processing During High-Level Cognitive Flexibility Tasks in Autistic Males and Females
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 40
- 主要终点
- Neurofunctional activity specificity of autistic adults in predictive processes during cognitive flexibility tasks
研究概览
简要总结
The goal of this study is to compare the neural correlates of predictive brain mechanisms during high-level social and non-social flexibility tasks, between autistic and non-autistic males and females. The aim is to better understand if autistic individuals differ from non-autistic individuals in their cognitive flexibility according to the social and predictable nature of the stimuli, at a behavioral and neurofunctional level using the functional Magnetic Resonance Imaging (fMRI). As autistic females usually present a more subtle profile than autistic males, the investigators will also explore if autistic males and females present neurofunctional differences.
详细描述
Background:
Autism spectrum conditions (ASC) may involve specificities in predictive brain mechanisms, which guide perception together with sensory input. These predictive mechanisms are at play in various aspects of life, such as social interactions, in which autistic individuals have difficulties. They are also important for cognitive flexibility, which involves changing tasks, strategies, or perspectives according to the situation. recent research highlighted that autistic individuals faced difficulties in flexibly adjusting their predictions to unpredictable social contexts during a socio-emotional flexibility task (social stimuli). However, they found no difference between autistic and non-autistic individuals during a cognitive flexibility task involving predictable changes of non-social stimuli. This study aims to more precisely investigate which conditions lead to flexibility difficulties in autism (i.e., the social context, the unpredictability, or both) and to investigate the brain networks involved in autistic and non-autistic participants during high-level cognitive flexibility tasks involving social and non-social stimuli. In addition, autistic females often presenting better socio-communicational abilities than autistic males and a different profile from males in past research involving cognitive flexibility, the investigators will explore if they present a different neurofunctional signature from males during these tasks.
Procedure:
The protocol begins with an imaging localization phase (5 minutes). Subsequently, functional MRI tasks (T2*) commence. The protocol consists of two cognitive tasks, performed within the MRI scanner, each preceded by a training phase. The acquisition of each participant's anatomical sequence (T1; 5 minutes) is conducted between the first two cognitive tasks to avoid compromising participant concentration. Finally, functional connectivity data are collected during a 'resting state' sequence (10 minutes). The study comprises a single visit.
Cognitive Tasks:
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •For non autistic individuals
- •Affiliation with social security scheme.
- •Registration in the national database of individuals willing to participate in research involving human subjects.
- •Absence of contraindications for MRI.
- •Signed informed consent before any study-related procedure.
- •Visual acuity allowing normal perception of stimuli or corrected vision.
- •Autism Quotient (AQ) (Baron-Cohen et al., 2001) <
- •For autistic individuals:
- •Affiliation with social security scheme.
- •Absence of contraindications for MRI.
- •Signed informed consent before any study-related procedure.
- •Visual acuity allowing normal perception of stimuli or corrected vision.
- •Diagnosis of autism established by a competent professional based on DSM/ICD criteria.
排除标准
- •Any subject with a vascular stent implanted less than 6 weeks before the examination.
- •Any subject with implanted biomedical material deemed "unsafe" or "not safe" in the list: http://www.mrisafety.com/TheList_search.asp.
- •Any acquisition procedure not meeting the conditions required for "conditional" use in subjects with implanted biomedical material classified as "conditional" in the list: http://www.mrisafety.com/TheList_search.asp.
- •Any subject with biomedical material such as a cardiac, neuronal, or sensory stimulator (cochlear implant due to the risk of demagnetization, heating, electrode, and artifacts) or a ventricular shunt valve without medical and paramedical supervision trained in MRI performance in these subjects.
- •Intraocular or intracranial ferromagnetic foreign body near nerve structures (risk of displacement and complications such as ocular or cerebral lesions).
- •Claustrophobia - Psychiatric or neurological conditions other than those specified.
- •Existence of a severe general health condition incompatible with the study: cardiac, respiratory, hematological, renal, hepatic, or cancerous.
- •Alcohol ingestion before the examination.
- •Persons covered by articles L1121-5 to L1121-8 of the Public Health Code (pregnant or breastfeeding women, minors or adults under legal protection, individuals under administrative or judicial surveillance).
- •Visual impairments.
- •Intellectual disability.
- •Inability to understand research instructions or provide informed consent.
结局指标
主要结局
Neurofunctional activity specificity of autistic adults in predictive processes during cognitive flexibility tasks
时间窗: during activation tasks
fMRI BOLD signal
次要结局
- SRS(through study completion, an average of 1 year)
- EQ(through study completion, an average of 1 year)
- Functional connectivity specificity of autistic adults(through study completion, an average of 1 year)
- EST accuracy(through study completion, an average of 1 year)
- AQ(through study completion, an average of 1 year)
- EST response time(through study completion, an average of 1 year)
- TST accuracy(through study completion, an average of 1 year)
- TST response time(through study completion, an average of 1 year)
- CAT-Q(through study completion, an average of 1 year)
- BRIEF-A(through study completion, an average of 1 year)
- WAIS-IV(through study completion, an average of 1 year)