Clinical Electrocochleography in Meniere's Disease: The Value of Low Frequency Stimulus Biasing

• Conditions: Diagnosing Meniere's disease in patients with vertigo; Ear - Other ear disorders

• Registration Number: ACTRN12607000230459
• Lead Sponsor: Dr Claire Iseli

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2007-05-01
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

All patients, undergoing electrocochleography for the investigation of vertigo under the care of Prof W Gibson will be invited to participate in the trial. The control group will be those with a very low Meniere's score obtained on clinical interview but are still undergoing electrocochleography -which is the current gold standard of diagnosis.

Exclusion Criteria

Hearing loss>70dB, concurrent ear pathology, stage 1 Meniere's - though the trial may change to include them based on initial results.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The change in Summation potential (SP) of the electrocochleograph result when the low frequency stimulus bias is introduced (from electrocochleography SP without stimulus biasing). [The summating potential is first measured in the response elicited to the 8kHz, 2kHz, 1kHz and 500Hz stimuli in the absence of the low frequency bias. Then the low frequency noise is made at the same time as the 8kHz, 2kHz, 1kHz and 500Hz stimuli and the SP generated is again measured for each of these frequencies. The change in the SP amplitude from before to after the introduction of the low frequency bias is then calculated.]

Secondary Outcome Measures

Name	Time	Method
Improvement in diagnosis of Meniere's disease when correlated with the current gold standard of clinical diagnosis. [The outcome is measured at the same time as the clinical interview and a direct correlation done comparing the electrocochleography results (with the added low frequency noise)with the clincial score and the basic electrocochleograph results. This is a cross sectional analysis of diagnosis compared between diagnostic tests - which included the clinical interview, which is the current gold standard. There is no secondary time point.]