Subcision With PRP and Microneedling Versus Subcision With Saline and Micro-needling in Treatment of Posttraumatic Scars

Not Applicable

Completed

• Conditions: Post-Traumatic Scar
• Interventions: Other: subcision ,PRP or saline and microneedling

• Registration Number: NCT06135480
• Lead Sponsor: Assiut University

Brief Summary

Compare different minimally invasive approaches to reach optimum improvement by comparing the efficacy and safety of both combined subcision with platelet-rich plasma and microneedling versus combined subcision with saline and microneedling in the treatment of post-traumatic scars.

Detailed Description

The scars at the level of the skin represent a normal and inevitable process of healing traumatic or surgical lesions, but except for the appearance of the skin, they also have a profound psychological impact . Thus, people with scars try to integrate them into their sense of self to gain psychological acceptance .

Many treatment options have been developed for the management of traumatic scars .Surgical intervention is an invasive technique, surgery has a high risk of inducing new scar formation .

Non-surgical approaches for the treatment of traumatic scars include topical treatments and minimally invasive approached as subcision,microneedling and laser.

Autologous platelet-rich plasma is plasma with a higher concentration of platelets than normally found, it can enhance wound healing which has been demonstrated in controlled studies for soft and hard tissues . The application of autologous platelet-rich plasma to surgical wounds has been shown to accelerate tissue repair and reduce postoperative pain .

Subcision is a procedure in which a needle is inserted under the skin and passed in multiple directions . Although subcision is adequate as a stand-alone treatment, improved results are achieved when it is combined with other modalities.

Microneedling is a percutaneous collagen induction therapy that causes skin resurfacing. It involves using fine needles to create controlled microdermal injuries starting a complex cascade of growth factors that end in collagen remodeling .

Because of the different treatment options available for this common problem, the current work aimed to combine and compare different minimally invasive approaches to reach optimum improvement.

Study Timeline

• Study Start: 2023-11-01
• Study First Submitted: 2023-11-12
• Study First Submitted QC: 2023-11-12
• Study First Posted: 2023-11-18
• Primary Completion: 2024-02-28
• Study Completion: 2024-03-30
• Status Verified: 2024-07
• Last Update Submitted: 2024-07-30
• Last Update Posted: 2024-07-31

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

• Patients with posttraumatic scars
• Age more than 12 years

Exclusion Criteria

• Patients with platelet or blood clotting disorders, and chronic liver or autoimmune diseases.
• Patients with chronic debilitating diseases, uncontrolled systemic infection, or keloid tendency or with unrealistic expectations.
• Pregnant females.
• Patients who did not complete the treatment sessions or the follow-up period.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
combined subcision with platelet-rich plasma and microneedling group	subcision ,PRP or saline and microneedling	-
combined subcision with saline and microneedling group	subcision ,PRP or saline and microneedling	-

Primary Outcome Measures

Name	Time	Method
Scar severity grading	after 1 month of treatment completion.	Scar severity grading will be evaluated by blinded dermatologist

Trial Locations

Locations (1)

Faculty of Medicine; 🇪🇬 Assiut, Egypt