Time course of serum interleukin-6 concentration during longer duration polymyxin B-immobilized fiber column hemoperfusio
Phase 2
- Conditions
- septic shock
- Registration Number
- JPRN-UMIN000016654
- Lead Sponsor
- Department of Emergency and Critical Care Medicine, Wakayama Medical University
- Brief Summary
See abovementioned URL.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 23
Inclusion Criteria
Not provided
Exclusion Criteria
Patients who have allergy for polymyxin B Pregnant or lactating women Patients who want to withdraw or withheld the treatment Attending physicians' decision
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Time course of serum IL-6 concentration during longer duration PMX-DHP
- Secondary Outcome Measures
Name Time Method Time course of hemodynamic variables during longer duration PMX-DHP Time course of blood gas analysis results during longer duration PMX-DHP Time course of ventilation and oxygenation variables (FiO2, PaO2/FiO2) during longer duration PMX-DHP Renal function (BUN, Cre, eGFR), urinary output and need for renal replacement therapy Length of ICU stay, and length of hospital stay 28 day mortality Duration of mechanical ventilation Acute physiology and chronic health evaluation II (APACHE II) score, sequential organ failure assessment (SOFA) score, and disseminated intravascular coagulation (DIC) score by the Japanese Association for Acute Medicine (JAAM) Laboratory marker of inflammation (white blood cell, c-reactive protein, presepsin and procalcitonin) Duration of antimicrobial therapy