Changes in Circulating Sclerostin Levels During Acute Postsurgical Hypoparathyroidism
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 109
- Locations
- 1
- Primary Endpoint
- change in circulating serum sclerostin levels (pmol/L) during the observation period
Study Overview
Brief Summary
To investigate changes in sclerostin levels following acute post-thyroidectomy hypoparathyroidism
Detailed Description
Female patients with thyroid disorders, referred to the Department of Head and Neck Surgery, at Metaxa Anti-Cancer Hospital of Piraeus, for total thyroidectomy.
Based on the development of biochemical hypocalcemia (cCa < 8.4 mg/dl), subjects were divided into 2 groups: Group A: without postsurgical hypoparathyroidism that served as controls and group B: subjects, with acute postsurgical hypoparathyroidism.
Blood collections were performed in the morning after an overnight fast, in at least 3 different time points; preoperatively, 1st postoperative day and 7th postoperative day for the detrmination of sclerostin levels
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 19 Years to — (Adult, Older Adult)
- Sex
- Female
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Indication for total thyroidectomy
Exclusion Criteria
- •parathyroid disorders, chronic kidney disease (eGFR< 60 ml/min), treatment with antiosteoporosis drugs, rheumatic disease and history of long term (>1 month) or current corticosteroid use
Arms & Interventions
Group B
Post-surgical hypoparathyroidism
Intervention: calcium carbonate and alphacalcidol (Drug)
Outcomes
Primary Outcomes
change in circulating serum sclerostin levels (pmol/L) during the observation period
Time Frame: 7 days
change in circulating serum sclerostin levels (pmol/L)during the observation period
Secondary Outcomes
- the between groups difference in % changes of circulating sclerostin(7 days)
Investigators
Symeon tournis
Senior Research Fellow
University of Athens