A comparative evaluation of nasal (Nasya Karma) and oral administration of Brahmi Ghrita in healthy volunteers to evaluate theMemory boosting effect.

Phase 1/2

Completed

• Conditions: to improve memory power

• Registration Number: CTRI/2015/08/006086
• Lead Sponsor: Institute for post graduate teaching and research in Ayurveda Gujarat Ayurved University Jamnagar

Brief Summary

This study was a randomized, open clinico-experimental trial. This study aims to evaluate the efficacy of nasal (Nasya) and oral administration of Brahmi Ghrita (Bacopa monnieri) as memory enhancer and cognitive enhancer in healthy volunteers, In this study 101 Healthy volunteers attending OPD and IPD of Panchakarma department IPGT and RA, GAU Jamnagar was selected and randomly divided into 3 groups. In Group A (classical Brahmi Ghrita nasally) 33 volunteers, in group B (Brahmi Ghrita internally) 34 volunteers and in Group C (cow ghee nasally) 33 healthy volunteers were completed the treatment and 1 healthy volunteers left before completion of treatment. The dose of Nasal and oral administration was 16 ml in the morning for 35 days. Brahmi Ghrita contain Bacopa monnieri and cow ghee.  Assessment was done by Manas Pariksha Bhava (metal examination) and PGI memory Scale before and after treatment.All groups were effective in memory enhancement in the healthy volunteers. Comparatively, Brahmi Ghrita Nasya(nasal administration) is more effective than other therapies under trial.   In the PGI memory scale, statistically significant improvement was found in parameters like Attention and Concentration, Delayed recall, immediate Recall, Retention for Dissimilar pairs and Visual retention. In Brahmi Ghrita Nasya when compared to Cow ghee Nasya, In some parameters like Delayed recall, Visual retention and Recognition, significantly higher results in Brahmi Ghrita Nasya (nasal administration)as compared to Brahmi Ghrita Snehapana (oral administration), proves the superiority of Nasyakarma (nasal admiration of drug ) over Snehapana(oral admiration of ghee)  in memory enhancing.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-06-08
• Last Update Posted: 2015-07-08

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

Healthy Volunteers between age group of 20 years to 60 years.

Exclusion Criteria

• 1)Healthy Volunteer having age less than 20 years & above 60 years.
• 2)Classical Nasya Karma Ayogya and Abhyantar Snehapana Ayogya volunteers.
• 3. Diabetes, any cardiovascular diseases, renal diseases or any other disease effecting multiple body systems and pregnant women etc.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
memory enhancer and cognitive enhancer in	35 days
healthy volunteers	35 days

Secondary Outcome Measures

Name	Time	Method
Analysis of effects of Brahmi Ghrita when	administrated nasally (Nasya) and orally with same dose

Trial Locations

Locations (1)

OPD and IPD of IPGTRA; 🇮🇳 Jamnagar, GUJARAT, India

OPD and IPD of IPGTRA

🇮🇳Jamnagar, GUJARAT, India

Dr Chetan M Gulhane

Principal investigator

9725519405

drchetanayu@gmail.com