Clinical study of life threatening complication of uncontrolled blood sugars

Not yet recruiting

Conditions: Diabetes mellitus due to underlying condition with ketoacidosis,

Registration Number: CTRI/2023/07/054731

Lead Sponsor: Kasturba Medical College Manipal

Brief Summary: The changing demographics of diabetes necessitates a need to analyse and evaluate the risk factors and clinical presentation of patients with ketoacidosis.There is an increasing frequency of euglycemic ketoacidosis due to introduction of SGLT2 inhibitors in the management of diabetes . Hence , this study aims to analyse the clinical presentation and the risk factors precipitating Diabetic Ketoacidosis, To analyse the biochemical profile of Diabetic Ketoacidosis, to co-relate the HbA1C levels with severity of Diabetic Ketoacidosis, to assess the complications and prognosis of Diabetic Ketoacidosis, To study the outcomes of Diabetic Ketoacidosis patients during treatment,To analyse the frequency of euglycemic ketoacidosis , clinical and biochemical profile of euglycemic ketoacidosis and prognosis of the same.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 100

Inclusion Criteria

Serum glucose >250mg /dl ( < 250 in case of Euglycemic ketoacidosis ) 2.
Serum bicarbonate concentra)on < 18 mmol/L 3.
Arterial pH <7.3 4.
Overt or significant ketonuria (more than 2+).

Exclusion Criteria

1.Post cardiopulmonary resuscitated patients 2.Late stages og CKD 3.Decompensated Chronic liver disease 4.Ketotic state like starvation ketosis, alcoholic ketosis, alcoholic ketosis 5.Drug or toxin induced acidosis.

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To Analyse the clinical presentation and the risk factors precipitating Diabetic Ketoacidosis.	AT BASELINE

Secondary Outcome Measures

Name	Time	Method
-Analyse the biochemical profile of Diabetic Ketoacidosis	1.Co-relate the HbA1C levels with severity of Diabetic Ketoacidosis.

Trial Locations

Locations (1): Kasturba Hospital, Kasturba Medical College, Manipal
🇮🇳
Udupi, KARNATAKA, India
Kasturba Hospital, Kasturba Medical College, Manipal
🇮🇳Udupi, KARNATAKA, India
Dr Aishwarya C
Principal investigator
9611232078
shwarya.c94@gmail.com