NCT07741578CompletedNot Applicable
The Impact of Sequential Order of Emergency Sedation and Neuromuscular Blocking Agent During Rapid Sequence Induction on Tracheal Intubation
Zhongnan Hospital1 site in 1 country380 target enrollmentStarted: July 1, 2025Last updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 380
- Locations
- 1
- Primary Endpoint
- First-pass success rate
Study Overview
Brief Summary
This clinical trial aims to understand the effect of the order of administration of Neuromuscular Blocking Agents (NMBAs) and sedatives on the success rate of intubation during Rapid Sequence Intubation (RSI) in the emergency department. The main questions to be answered include:
- The impact of sequential drug administration order during rapid sequence induction (RSI) on first-pass intubation success rates.
- Time to successful intubation
- Hypoxia incidence (SpO₂ <90%)
- Risk of post-traumatic stress disorder (PTSD)
- Procedure-related complications
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Other
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •in ED/EICU required emergency intubation
- •RSI required
Exclusion Criteria
- •Pregnancy
- •do not intubation orders
- •Declined participation
- •Other trials
- •Non-emergent cases
- •Active CPR
Outcomes
Primary Outcomes
First-pass success rate
Time Frame: Perioperative
Successful intubation on the first attempt, confirmed by any one of: Direct visualization of the ETT passing through vocal cords Bilateral breath sounds on auscultation Fiberoptic bronchoscopic confirmation of tracheal placement Sustained end-tidal CO₂ waveform (EtCO₂ \>15 mmHg for ≥3 breaths)
Secondary Outcomes
- Changes in HR(Perioperative)
- Time to intubation(Perioperative)
- Intubation recall(From drug injection to Remove the endotracheal tube)
- Changes in SBP(Perioperative)
- Changes in SpO₂(Perioperative)
Investigators
Study Sites (1)
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