method VALIDation and evaluation of non-radioactive methods to measure Glomerular Filtration Rate
- Conditions
- Chronic Kidney Disease Kidney Failure
- Registration Number
- 2023-509156-34-02
- Lead Sponsor
- Universitair Medisch Centrum Groningen
- Brief Summary
To determine the equivalence of mGFR using 125I-iothalamate and 131I-hippuran versus iohexol
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Authorised, recruiting
- Sex
- Not specified
- Target Recruitment
- 200
Scheduled to undergo a kidney function measurement test as part of standard care
Age ≥ 18 years
Written informed consent
History of hypersensitivity to iodinated contrast media or one of the excipients in the formulation of iohexol (trometamol, sodium calcium edetate, hydrochloric acid).
Subjects with (suspected or known) thyrotoxicosis.
Pregnant women and women of child-bearing potential who are not using reliable contraception
Patients who are unlikely to comply to the trial’s procedure (non-compliance)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method mGFR determined using iohexol mGFR determined using iohexol
mGFR determined using 125I-Iothalamate and 131I-hippuran mGFR determined using 125I-Iothalamate and 131I-hippuran
- Secondary Outcome Measures
Name Time Method Repeated mGFR using iothalamate and hippuran on a separate study day Through study completion, an average of 1 year mGFR that is determined using the warm 125I-iothalamate and 131I-hippuran method
Repeated mGFR using iohexol on a separate study day Through study completion, an average of 1 year mGFR that is determined using the iohexol method
Trial Locations
- Locations (1)
Universitair Medisch Centrum Groningen
🇳🇱Groningen, Netherlands
Universitair Medisch Centrum Groningen🇳🇱Groningen, NetherlandsRon GansevoortSite contact+310503612955r.t.gansevoort@umcg.nl