Myocardial Blood Flow by 15O Water PET

Completed

• Conditions: Coronary Heart Disease
• Interventions: Other: Computed tomography myocardial perfusion imaging; Other: Oxygen 15 labelled water positron emission tomography

• Registration Number: NCT01805193
• Lead Sponsor: University of Edinburgh

Brief Summary

Coronary heart disease is a very common condition caused by narrowings in the blood vessel supplying the heart. the investigators are studying new tests to diagnose heart disease. In this study the investigators plan to investigate a special scan called a PET/CT (Positron emission tomography/computed tomography) and a new type of CT (Computed tomography) scan to tell us about the flow of blood to the heart muscle.

Detailed Description

Participants will undergo PET/CT with oxygen-15 labelled water and computed tomography myocardial perfusion imaging.

Study Timeline

• Study Start: 2012-12
• Study First Submitted: 2013-02-04
• Study First Submitted QC: 2013-03-04
• Study First Posted: 2013-03-06
• Primary Completion: 2014-06
• Study Completion: 2019-01
• Status Verified: 2019-02
• Last Update Submitted: 2019-02-21
• Last Update Posted: 2019-02-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 22

Inclusion Criteria

• suspected coronary artery disease

Exclusion Criteria

• inability or unwillingness to undergo CT or PET imaging
• renal failure (serum creatinine >200 um/L or eGFR <30 ml/min)
• hepatic failure
• allergy to iodinated contrast
• pregnancy
• contraindication to adenosine
• inability to give informed consent
• atrial fibrillation with a fast ventricular rate (>70 beats per minute)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Suspected coronary heart disease	Oxygen 15 labelled water positron emission tomography	-
Suspected coronary heart disease	Computed tomography myocardial perfusion imaging	-

Primary Outcome Measures

Name	Time	Method
Myocardial blood flow	1 month	Myocardial blood flow ( ml/g/min) measured by oxygen-15 water positron emission tomography

Secondary Outcome Measures

Name	Time	Method
Fractional flow reserve	1 month	Fractional flow reserve measured during invasive coronary angiography
Myocardial perfusion	1 month	Myocardial perfusion measured as hypoperfusion on adenosine computed tomography myocardial perfusion imaging

Trial Locations

Locations (1)

Clinical Research Imaging Centre; 🇬🇧 Edinburgh, Scotland, United Kingdom