The Risk Factors for Perioperative Blood Transfusion in Open Liver Resection, a Retrospective Cohort Study Development of a Transfusion Scoring System to Predict the Requirement for Perioperative Blood Transfusion in Open Liver Resection
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 1,201
- 主要终点
- the pre-operative risk factors of perioperative packed red cell transfusions in open liver resection procedures.
研究概览
简要总结
This observational study is specifically designed to identify the pre-operative risk factors that significantly contribute to perioperative packed red cell transfusions in open liver resection procedures.
The main question it aims to answer are:
- What are the risk factors of peri-operative blood transfusion in open liver resection procedures
- What are the difference outcomes between patients who receive blood transfusion and the other group.
Researcher will compare perioperative factor and post operative outcomes between transfused and non-transfused group
详细描述
After approval of the study protocol from the institutional review board of Chiangmai University (Approval number: ANE-2564-08020), we performed a retrospective review of all patients who underwent an elective open liver resection in our specialized hepato-biliary center from January 2006 through December 2017. This retrospective inquiry comprised 808 patients.
The data was systematically retrieved from electronic medical records. Baseline characteristics including age, gender, body mass index (BMI), co-morbidity, American Society of Anesthesiologists (ASA) classification, diagnosis, hepatitis profile, Child-Pugh classification, cirrhosis, the largest tumor size, previous liver resection, and pre-operative laboratory investigations were collected.
The following intra-operative data were collected: type of liver resection, hilar resection, vascular reconstruction, volume and type of fluid administration, estimated blood loss, packed red cell and blood product transfusion, and operation time. The definitions of liver resection and the type of hepatectomy were aligned with the anatomic classification of the Brisbane 2000 Terminology
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All genders age above 18 year old who underwent open liver resection from 2006-2017
- •Elective open liver resection
排除标准
- •Patients who death during the course of a surgical operation
结局指标
主要结局
the pre-operative risk factors of perioperative packed red cell transfusions in open liver resection procedures.
时间窗: the transfusion of packed red cells during the operation and 48 hours after surgery
Significant risk factors for perioperative blood transfusion were determined by factors with a p-value \< 0.05 derived from the multivariable logistic regression analysis. This analysis facilitated adjustments for potential confounders to identify the independent risk factors associated with perioperative blood transfusion
次要结局
未报告次要终点
研究者
Warangkana Lapisatepun
Assistant professor
Chiang Mai University
