NCT03107390终止不适用
Evaluation of NT-proBNP in Chronic Inflammatory Bowel Disease
适应症
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 159
- 试验地点
- 2
- 主要终点
- Blood level of NTproBNP.
研究概览
简要总结
NT-proBNP is a major diagnostic and prognostic marker in cardiology, but it is also a new marker for biological inflammation, especially in rheumatology.
Its evaluation in chronic inflammatory bowel disease was carried out in a preliminary study, the OPERA study where in a population of 12 patients showed an increase in NT-proBNP correlated with the biological and endoscopic activity of the disease. This larger study is therefore a pilot study that could see NTproBNP as a new biomarker of inflammation in MICI.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult subjects (age 18 years)
- •MICI Group: Patients monitored for probable HC or MC
- •Control group: Patients referred for consultation in gastroenterology with a clinical and endoscopic picture eading to the diagnosis of TF I
- •Person who agreed to participate in the study
- •Patient covered by social insurance
排除标准
- •Causes of increased concentrations of natriuretic peptides: acute heart failure, acute or chronic pulmonary disease with right ventricular repercussion, valvulopathies, primary or secondary HVG, atrial fibrillation cardiac arrhythmia, chronic systolic dysfunction, hyperthyroidism, Addison's disease, hyperaldosteronism Primary, diabetes, cirrhosis with ascites, cancers, chronic renal insufficiency.
- •Inflammatory and autoimmune diseases (excluding MC and RCH), chronic inflammatory syndrome
- •Ongoing treatment that may affect the concentration of natriuretic peptides: ACE inhibitor, angiotensin II receptor antagonists, diuretics
- •Patient deprived of liberty or protected major (under guardianship or curatorship)
结局指标
主要结局
Blood level of NTproBNP.
时间窗: 1 month
次要结局
未报告次要终点
研究者
研究点 (2)
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