Verification of the Safety of Early Discharge in Patients After Acute ST-segment Myocardial Infarction

Not Applicable

Completed

Conditions: Coronary Artery Disease
Early Discharge
Acute Myocardial Infarction With ST-segment Elevation
Primary Percutaneous Coronary Intervention

Brief Summary: The aim of the study is to prove that early discharge (within 72 hours) in selected group of patients after myocardial infarction with elevations of ST-segment is feasible and safe

Detailed Description: The aim of the study is to prove

* that early discharge (within 72 hours) in selected group of patients with low risk of follow-up complications after myocardial infarction with elevations of ST-segment, treated with primary percutaneous coronary intervention, is feasible and safe

* that early discharge is comparable with the group of patients, discharged in a standard way accordingly with present practice and physician´s decision (usually 4th-7th day), thus it is not associated with higher incidence of complications in 90th day after myocardial infarction

Recruitment & Eligibility

Inclusion Criteria

Signed informed consent
Age ≥18 do ≤ 75 years
Acute myocardial infarction with ST-segment elevation, treated with successful percutaneous coronary intervention within 12 hours from the onset of symptoms
Left ventricle ejection fraction ≥ 45% by echocardiography
Single- or two-vessel disease (stenosis of major epicardial artery ≥ 70%)
Haemodynamic and rhythmic stability (Killip class I, no arrythmia requiring treatment occurring > 2 hours after PCI)
Assumed good cooperation and social background

Exclusion Criteria

Symptoms of residual ischemia
Significant comorbidities or abnormalities in paraclinical tests, requiring additional evaluation within continuing hospitalization
Contraindication of dual antiplatelet therapy or need for anticoagulation therapy
Hihg risk of bleeding complications
Participation in other clinical study

Arm && Interventions

Group	Intervention	Description
Standard discharge	Standard discharge	-
Early discharge	Early discharge	-

Primary Outcome Measures

Name	Time	Method
Composite of Incidence of Death, Reinfarction, Unstable Angina Pectoris, Stroke, Unplanned Rehospitalization, Repeat Target Vessel Revascularization and Stent Thrombosis in 90 Days After Myocardial Infarction (MI)	90 days	Fischer´s exact test was used for comparison of qualitative variables between two groups. For comparison of quantitative variables we applied Mann-Whitney U test, respectively Student´s t-test (age). Normality of data was assessed with Shapiro-Wilk test. Values of p \< 0.05 were considered as statistically significant.

Secondary Outcome Measures

Name	Time	Method
Complications Associated With the Puncture Site Requiring Treatment in 30 Days After Myocardial Infarction (MI)	30 days	Fischer´s exact test was used for comparison of qualitative variables between two groups. For comparison of quantitative variables we applied Mann-Whitney U test, respectively Student´s t-test (age). Normality of data was assessed with Shapiro-Wilk test. Values of p \< 0.05 were considered as statistically significant.