Bright Light as a Countermeasure for Circadian Desynchrony

Not Applicable

• Conditions: Healthy

• Registration Number: NCT01119365
• Lead Sponsor: VA Palo Alto Health Care System

Brief Summary

Light is the primary means by which the internal circadian clock remains aligned ("entrained") with the external world. Misalignment of this internal clock can occur during situations such as shift work and jet travel across multiple time zones (jet lag). The purpose of this study is to examine how sequences of brief flashes of light can affect entrainment of the clock.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2010-05-05
• Study First Submitted QC: 2010-05-06
• Study First Posted: 2010-05-07
• Study Start: 2011-07
• Status Verified: 2022-03
• Last Update Submitted: 2022-03-28
• Last Update Posted: 2022-04-06
• Primary Completion: 2023-06
• Study Completion: 2023-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

• Good health
• Normal hearing

Exclusion Criteria

• Sleep disorder
• Extreme chronotype
• Regular smoker
• Depression
• Alcohol abuse
• Illegal drug use

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Circadian phase	2 days	The timing of the onset of melatonin is compared before and after a light stimulus

Secondary Outcome Measures

Name	Time	Method
Alertness	1 hour	Alertness as assessed through change in brain wave (electroencephalographic, EEG) activity, questionnaires, and objective testing is examined before and at the end of a light stimulus

Trial Locations

Locations (1)

VA Palo Alto Health Care System; 🇺🇸 Palo Alto, California, United States