A Randomized Trial of Itraconazole in Acute Stages of Allergic Bronchopulmonary Aspergillosis
- Conditions
- Allergic Bronchopulmonary Aspergillosis
- Interventions
- Drug: Glucocorticoids
- Registration Number
- NCT02440009
- Lead Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
- Brief Summary
The study evaluates the addition of itraconazole to glucocorticoids in management of acute stages of allergic bronchopulmonary aspergillosis (ABPA). Half of the participants will receive glucocorticoids while the other half will receive itraconazole and glucocorticoids
- Detailed Description
The management of allergic bronchopulmonary aspergillosis (ABPA) includes two important aspects namely institution of immunosuppressive therapy in the form of glucocorticoids to control the immunologic activity, and close monitoring for detection of relapses. Another possible target is to use antifungal agents to attenuate the fungal burden secondary to the fungal colonization in the airways. Oral corticosteroids are currently the treatment of choice for ABPA associated with bronchial asthma. They not only suppress the immune hyperfunction but are also anti-inflammatory.
Itraconazole, an oral triazole with relatively low toxicity, is active against Aspergillus spp. in vitro and in vivo. The activity of itraconazole against Aspergillus spp. is more than that of ketoconazole. The administration of itraconazole can eliminate Aspergillus in the airways and can theoretically reduce the allergic responses in ABPA. We hypothesize that itraconazole when given in the acute stages of ABPA will decrease the chances of relapse and progression to glucocorticoid-dependent ABPA.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 191
Treatment naive patients of allergic bronchopulmonary aspergillosis (ABPA) defined by the presence of all the following:
- asthma
- immediate cutaneous hyperreactivity on Aspergillus skin test or A.fumigatus specific IgE levels >0.35 kUA/L
- elevated total IgE levels >1000 IU/mL and, two of the following features:
- presence of precipitating antibodies against A.fumigatus in serum
- fixed or transient radiographic pulmonary opacities
- total eosinophil count >1000/µL
- bronchiectasis on HRCT chest
- Intake of systemic glucocorticoids for more than three weeks in the preceding six months
- Exposure to azoles in the last six months
- Immunosuppressive states such as uncontrolled diabetes mellitus, chronic renal failure, chronic liver failure and others
- Patient on immunosuppressive drugs
- Pregnancy
- Enrollment in another trial of ABPA
- Failure to provide informed consent
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Glucocorticoid group Glucocorticoids Oral prednisolone 0.5 mg/kg/day for 4 weeks; 0.25 mg/kg/day for 4 weeks; 0.125 mg/kg/day for 4 weeks. Then taper by 5 mg every 4 weeks and discontinue by the end of 4 months. Patients will also receive inhaled formoterol/fluticasone (6/125 mcg) 1 puff BD and as needed as per the SMART approach for control of asthma Itraconazole plus glucocorticoid group Glucocorticoids Oral itraconazole 200 mg BD for 6 months AND oral prednisolone 0.5 mg/kg/day for 4 weeks; 0.25 mg/kg/day for 4 weeks; 0.125 mg/kg/day for 4 weeks. Then taper by 5 mg every 4 weeks and discontinue by the end of 4 months. Patients will also receive inhaled formoterol/fluticasone (6/125 mcg) 1 puff BD and as needed as per the SMART approach for control of asthma. Itraconazole plus glucocorticoid group Itraconazole Oral itraconazole 200 mg BD for 6 months AND oral prednisolone 0.5 mg/kg/day for 4 weeks; 0.25 mg/kg/day for 4 weeks; 0.125 mg/kg/day for 4 weeks. Then taper by 5 mg every 4 weeks and discontinue by the end of 4 months. Patients will also receive inhaled formoterol/fluticasone (6/125 mcg) 1 puff BD and as needed as per the SMART approach for control of asthma.
- Primary Outcome Measures
Name Time Method Glucocorticoid-dependent ABPA 24 months If the patient has relapse on two or more consecutive occasions within 6 months of stopping treatment or requires oral steroids for control of asthma
Relapse rates 12 months Doubling of the baseline IgE levels irrespective of the patient's symptoms or appearance of radiologic infiltrates; or clinical and/or radiological worsening with 50% increase in IgE over the previous baseline value
- Secondary Outcome Measures
Name Time Method Percentage decline in IgE Six weeks Proportion of patients with a response rates Six weeks Treatment-related adverse effects Six months Time to first relapse Two years
Trial Locations
- Locations (1)
Chest Clinic, PGIMER
🇮🇳Chandigarh, India