Silent Ureteral Stone: Impact on Renal Function and Kidney Anatomy

Not Applicable

• Conditions: Urinary Calculi
• Interventions: Procedure: Surgical Treatment

• Registration Number: NCT01884870
• Lead Sponsor: University of Sao Paulo

Brief Summary

Ureteral stones may be silent in 5.3% of patients. The goal of this study was to prospectively evaluate the impact of a silent ureteral stone on renal function.

Detailed Description

The prevalence of nephrolithiasis is increasing worldwide, reaching 5.2% in North America and 10.1% in Italy. The widespread use of computed tomography and ultrasonography have resulted in a greater detection rate of asymptomatic stones and, in part, might explain the trend. Clinically, kidney or ureteral stones range in severity from asymptomatic to presenting with complete renal failure. Therefore, it is not only the alarming incidence of urinary stone disease, but also the associated burden that makes this one of the most concerning conditions in public health.

The situation becomes even more distressing when managing asymptomatic stones. Studies of the natural history of stones have revealed that only 20% of patients yearly actually become symptomatic from a new stone, and one half of those require surgical intervention at some point. The guidelines are well established for the treatment of symptomatic urolithiasis, and many investigators have extensively studied the management of silent kidney stones. Conversely, the same is not true for silent ureterolithiasis. The purpose of the present study is to report the investigators experience managing silent ureteral stones and to prospectively analyze their true influence on renal function.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2012-11
• Study First Submitted: 2013-06-19
• Study First Submitted QC: 2013-06-21
• Study First Posted: 2013-06-24
• Status Verified: 2015-06
• Last Update Submitted: 2015-06-02
• Last Update Posted: 2015-06-04
• Primary Completion: 2015-07
• Study Completion: 2015-08

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

• Silent ureteral stone: no subjective/objective symptoms related to the ureteral calculi.
• Patient willing to participate in the study
• Complete pre/post-operative work-up

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Exclusion Criteria

• Treatment outside our institution
• No will to be a part of the study
• Incomplete pre/post-operative work-up

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Surgical Treatment	Surgical Treatment	Silent Ureteral Stone - Surgical Treatment

Primary Outcome Measures

Name	Time	Method
Ipsilateral Renal Function	1 year	Ipsilateral renal function determined by dimercaptosuccinic acid scintigraphy (DMSA) 12 months after surgery.

Secondary Outcome Measures

Name	Time	Method
Estimated Creatinine Clearance	1 year	Estimated Creatinine Clearance
Renal Anatomy assessed by Ultrasound	1 year	Renal Anatomy assessed by Ultrasound
Serum Creatinine level	1 year	Serum Creatinine level

Trial Locations

Locations (1)

Clinics Hospital - University of Sao Paulo Medical School; 🇧🇷 Sao Paulo, SP, Brazil