RElevance of Biomarkers for Future Risk of Thromboembolic Events in UnSelected Post-myocardial Infarction Patients - an Observational Study (REBUS)
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Myocardial Infarction
- Sponsor
- Uppsala University
- Enrollment
- 425
- Locations
- 1
- Primary Endpoint
- Death, myocardial infarction, stroke
- Status
- Completed
- Last Updated
- 12 years ago
Overview
Brief Summary
The study is an open, single center, observational study at the Cardiology Dept at Uppsala University Hospital. The number of patients included will be 410. The objectives are to:
Evaluate biomarkers and change of these related to myocardial infarction, during two years follow-up in an unselected patient population with a recent myocardial infarction.
Evaluate if an early change of biomarkers can be related to death, new myocardial infarction, and ischemic stroke in the same population after two and five years follow-up.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Myocardial infarction diagnosed by dynamic raised troponin I with at least one value above 0.1 µg/L. Together with at least one of the criteria; symptoms suggestive for myocardial infarction or development of significant Q wave.
- •Treated at the Department of cardiology, Uppsala University Hospital.
- •Ability to attend the scheduled visits for evaluation procedures.
- •Signed Informed Consent.
Exclusion Criteria
- •Death ≤ 5 days after the myocardial infarction.
- •Not belonging to the catchment area of Uppsala University Hospital.
- •Lack of suitability for participation in the trial, for any reason, as judged by the Investigator.
Outcomes
Primary Outcomes
Death, myocardial infarction, stroke
Time Frame: Five years from study start
Death: Death will be sub-classified by vascular or non-vascular primary cause. All deaths with unknown/uncertain cause will be categorized as vascular death. Myocardial Infarction(MI): Rehospitalization due to new non fatal MI or development of significant Q-wave. Stroke: Diagnosed as abrupt onset of focal neurological deficit persisting more than 24 hours.
Secondary Outcomes
- Venous thromboembolism, Arterial embolism, Bleeding(Five years from study start)