NCT01630317Unknown不适用
Slow Continuous Ultrafiltration Using Central vs Peripheral Line: Feasibility of Implementation, Safety and Efficacy in Acute Heart Failure Syndromes.
Parc de Salut Mar2 个研究点 分布在 1 个国家目标入组 33 人开始时间: 2011年11月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 33
- 试验地点
- 2
- 主要终点
- Efficacy
研究概览
简要总结
Slow continuous ultrafiltration using central vs peripheral line: feasibility of implementation, safety and efficacy in acute heart failure syndromes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •≥ 18 years
- •Patients hospitalized with primary diagnosis of acute heart failure defined as ≥ 2 of the following criteria:
- •Peripheral or sacral edema
- •Jugular venous distension or venous central pressure > 10 mmHg
- •Hepatomegaly or ascites
- •Pulmonary edema or pleural effusion on x-ray or pulmonary wedge pressure or end-diastolic pressure > 20 mmHg.
- •High pro-BNP
- •Randomization during first 24 hours
- •Serum creatinine levels < 3mg/dL, and K < 6 mmol/L
- •The patient should be able to communicate with research staff and meet with study procedures.
- •The patient will signed informed consent.
排除标准
- •Diagnosis of severe aortic stenosis or severe obstruction to the LVOT, tamponade, cardiac hypertrophic or restrictive cardiomyopathy.
- •Impossibility of venous catheterization
- •Acute coronary syndrome
- •Creatinine greater than 3.0 or K greater than 6 mmol/L.
- •Systolic blood pressure less than or equal to 100 mmHg
- •Hematocrit greater than 45%
- •Prior administration of IV vasoactive drugs in the emergency room (ER)
- •Clinical instability requiring pressors during hospitalization
- •On or requires renal dialysis.
结局指标
主要结局
Efficacy
时间窗: 48 hours after initiation of scuf therapy
Compare patient global improvement 48 hours after initiation of scuf therapy in a group of patients with the same features treated by peripheral access against a group of patients with the same features treated by central access. This outcome will be measured by patient global assessment
次要结局
- Security(5th day of the study)
研究者
Nuria Ribas
Nuria Ribas
Parc de Salut Mar
研究点 (2)
Loading locations...
相似试验
已完成
不适用
Feasibility of Slow Continuous UltraFiltration For Deresuscitation in Critically Ill PatientsFluid OverloadNCT05431491Belfast Health and Social Care Trust18
已完成
不适用
Continuous Hemofiltration During Cardiopulmonary Bypass and Its Effect on LactatemiaCardiovascular DiseasesNCT03412968University of Cadiz76
终止
不适用
PURE-HF: Peripheral Ultrafiltration for the RElief From Congestion in Heart FailureHeart FailureAcute Heart FailureNCT03161158Fresenius Medical Care Deutschland GmbH62
已完成
不适用
The optimal ultrafiltration method in cell-free and concentrated ascites reinfusion therapyPatients with refractory cancerous ascitesJPRN-UMIN000025382Fujita Health University School of Medicine9
撤回
不适用
Ultrafiltration (Aquapheresis) in Patients With Leukemia and Severe Fluid OverloadLeukemiaNCT01508260M.D. Anderson Cancer Center