Value of PET/CT Imaging in the Diagnosis of Permanent Central Venous Catheters Infection

Completed

• Conditions: Infection

• Registration Number: NCT01434797
• Lead Sponsor: University of Lausanne Hospitals

Brief Summary

The study hypothesis is that F-18-FDG PET/CT and microcalorimetry might have a diagnostic value in the detection of permanent central venous catheters (PCVC) infection when conventional means of PCVC infection detection are non-conclusive.

Detailed Description

Permanent central venous catheters are frequently infected and therefore need surgical removal. When a clear diagnostic for infection cannot be defined, catheter removal might be at risk for the patient, for the therapeutic follow-up and in terms of costs. PET/CT and microcalorimetry might help giving conclusive diagnostic of catheter infection.

Study Timeline

• Study Start: 2011-09
• Study First Submitted: 2011-09-01
• Study First Submitted QC: 2011-09-13
• Study First Posted: 2011-09-15
• Primary Completion: 2014-11
• Status Verified: 2020-03
• Study Completion: 2020-03
• Last Update Submitted: 2020-03-29
• Last Update Posted: 2020-03-31

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 11

Inclusion Criteria

• patients with confirmed catheter infection requiring surgical removal
• patients with probable catheter infection requiring surgical removal
• patients with planned removal of uninfected catheter
• ≥18years old

Exclusion Criteria

• extreme claustrophobia
• pregnancy and breastfeeding
• severe septicemia

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Diagnostic value (sensitivity and sensibility, positive/negative predictive value) of F-18-FDG PET/CT imaging in the detection of CVCP infection	6 months	To determine the clinical use of PET/CT in the detection of catheter infection by comparing PET/CT imaging results to standard means of catheter infection detection (i.e. clinical signs and hemoculture \[positive or negative\])

Secondary Outcome Measures

Name	Time	Method
Diagnostic value (sensitivity and sensibility, positive/negative predictive value) of microcalorimetry in the detection of CVCP infection	6 months	To determine the clinical use of microcalorimetry in the detection of catheter infection by comparing microcalorimetry results to standard means of catheter infection detection (i.e. clinical signs and hemoculture \[positive or negative\])

Trial Locations

Locations (1)

Centre Hospitalier Universitaire Vaudois, Nuclear Medicine; 🇨🇭 Lausanne, Vaud, Switzerland