Angiomatoid Fibrous Histiocytoma: a Single Institution Case-series
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 9
- 试验地点
- 1
- 主要终点
- selection and review of 9 cases of Angiomatoid Fibrous Histiocytoma
研究概览
简要总结
single institution cases series review of histological and clinical data
详细描述
single institution cases series review of histological and clinical data Investigators will retrieve from the archives of the Rizzoli Institute all the cases with a histological diagnosis of Angiomatoid Fibrous Histiocytoma. In all cases with enough available material, immunohistochemistry will be performed on slides/formalin-fixed paraffin-embedded tissue tumor material.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Other
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Male and female patients treated at Rizzoli Institute from 01 January 2006 to 31 December 2017
- •Diagnosis of Angiomatoid Fibrous Histiocytoma
- •Histological slides/formalin-fixed paraffin-embedded tissue tumor (FFPE) blocks from archive available to perform the histology analysis
- •Written informed consent prior to any study-specific analysis and/or data collection
排除标准
- •Patients with histological diagnosis different from Angiomatoid Fibrous Histiocytoma
结局指标
主要结局
selection and review of 9 cases of Angiomatoid Fibrous Histiocytoma
时间窗: at baseline (Day0)
investigators will review all the medical records, radiological imaging, and histological slides of all cases to identify the best therapeutic approach.
analysis of EWS-CREB1 and EWS-ATF1 mutation and ALK expression on tissue tumor material
时间窗: at baseline (Day0)
In all cases immunohistochemistry will be performed on slides/formalin-fixed paraffin-embedded tissue tumor material. EWS-CREB1 and EWS-ATF1 mutation and ALK expression will be analyzed with RT-PCR and/or FISH analysis.
次要结局
未报告次要终点