Mikrobiologi Ved Para- og Retropharyngeal Absces
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 72
- 试验地点
- 5
- 主要终点
- Bacterial findings in aerobic and anaerobic cultures and MALDI-TOF mass spectrometry from para- and retropharyngeal abscesses
研究概览
简要总结
The aims of the study are:
- Explore the bacteriology of para- and retropharyngeal abscess.
- Validate the bacterial findings by exploring antibody development against F. necrophorum, F. nucleatum and S. pyogenes.
- Compare bacteriologic findings in concomitant peritonsillar and parapharyngeal abscesses.
- Characterize patients with para- and retropharyngeal abscess.
- Compare the concentration of amylase in para- and retropharyngeal abscesses and neck abscesses without relation to the pharynx or salivary glands.
- Perform gene-sequencing of F. Necrophorum strains, and compare these with strains recovered from patients with acute tonsillitis, peritonsillar abscess, and Lemierre´s syndrome.
详细描述
Patients:
Sixty patients aged 18 years or older with para- or retropharyngeal abscess and 12 patients with neck abscess without relation to the pharynx or salivary glands (controls) will be included at five Danish centers. Estimated time of inclusion: Four years.
Data:
Symptoms, findings, and other relevant information will be obtained at admission. Data regarding treatment and complications will be obtained after discharge.
Samples:
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •para- or retropharyngeal abscess
排除标准
- •refuse to participate
结局指标
主要结局
Bacterial findings in aerobic and anaerobic cultures and MALDI-TOF mass spectrometry from para- and retropharyngeal abscesses
时间窗: Within eight hours of patient admission
Prevalence of potential bacterial pathogens (F. necrophorum, F. nucleatum, Prevotella species, Group A streptococcus, Group C/G streptococcus (large colony forming), S. aureus, H. influenzae, and Viridans streptococci) recovered from aerobic and anaerobic bacterial cultures from pus aspirates.
次要结局
- Comparison of bacterial recoveries in aerobic and anaerobic cultures from patients with concomitant peritonsillar and para-retropharyngeal abscess.(Within eight hours of patient admission.)
- Amylase concentrations in para- and retropharyngeal abscesses vs neck abscesses without relation to the pharynx or salivary glands(Within eight hours of patient admission.)
- Antibody Development against F. necrophorum, F. nucleatum, and S. pyogenes in patients with para- and retropharyngeal abscess(Within eight hours of patient admission (serum 1) and two to four weeks after admission (serum 2))
研究者
Tejs Ehlers Klug
Consultant, associate professor
Aarhus University Hospital