Enhancing cognition in bipolar disorder

Suffolk Mental Health Partnership NHS Trust (UK)0 sites20 target enrollmentJuly 16, 2007

Overview

No summary available.

Registry

who.int

Start Date

July 16, 2007

End Date

TBD

Last Updated

11 years ago

Study Type

Interventional

Sex

All

Sponsor

Suffolk Mental Health Partnership NHS Trust (UK)

•1\. All patients must be able to give informed written consent to participate in the study
•2\. Aged 18 to 65
•3\. English should be spoken fluently
•4\. Participants should be literate and have normal or corrected to normal eyesight
•5\. All patients must have met Diagnostic and Statistical Manual of Mental Disorders \- Fourth Edition (DSM IV) criteria for Bipolar I disorder in the past i.e. they must have had an episode of mania or a mixed affective state
•6\. The Hamilton Depression Rating Scale and Young Mania Scale scores must both be less than eight

•1\. Patients who currently fulfill criteria for mania, a mixed affective state, hypomania or major depression
•2\. Patients who score less than or equal to 24 on the Mini\-Mental State Examination (MMSE). All patients with a diagnosis of dementia will be excluded after review of case\-records and/or discussion with their clinician
•3\. Current diagnosis of alcohol or drug dependence based on DSM IV criteria
•4\. History of learning disability (or Wechsler test of Adult Reading score \<90\) or dyslexia
•5\. Any known neurological illness (including narcolepsy)
•6\. Unstable medical illness that may affect cognition (untreated thyroid disease, type I diabetes mellitus or current treatment with steroids)
•7\. Have received electroconvulsive therapy in the past three months
•8\. Patients taking herbal remedies such as St John?s Wort or Gingko Biloba
•9\. Moderate or severe hypertension. All patients should have blood pressure measurements within normal limits (i.e. systolic blood pressure less than or equal to 160 and diastolic blood pressure less than or equal to 90\) prior to drug administration
•10\. Known history of angina or cardiac arrhythmias