Markers of Prognosis and Response to Therapy in Patients With Metastatic Brain Tumors Undergoing Stereotactic Radiosurgery (SRS)
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Quantitative measures of overall tumor volume will be performed for each subject at the time of SRS
研究概览
简要总结
This registry study will evaluate patients with metastatic brain tumors undergoing, or having undergone, stereotactic radiosurgery (SRS) at Swedish Medical Center. Clinical outcomes will be evaluated at the 3, 6 and 12-month time points. Clinical data, SRS treatment data, and imaging data (including anatomic and advanced imaging sequences obtained prior to and serially following SRS) will be archived in an online informatics platform, specifically a metastatic brain tumor registry known as the Comprehensive Neuro-oncology Data Repository for Metastatic Tumors (CONDR - Mets).
研究设计
- 研究类型
- Observational
- 时间视角
- Prospective
入排标准
- 年龄范围
- 19 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients (>18 yo) with a pathological diagnosis of metastatic brain cancer
- •Participants must have >4 tumors felt to require stereotactic radiosurgery
- •Karnofsky scale of > 70 at the time of initial treatment
- •Age < 80
排除标准
- •Karnofsky scale <70
- •Age > 80
- •Inability to undergo MR imaging studies
结局指标
主要结局
Quantitative measures of overall tumor volume will be performed for each subject at the time of SRS
时间窗: At the time of SRS
Quantitative measures of tumor number will be performed for each subject at the time of SRS
时间窗: At the time of SRS
Overall survival will be measured for each subject (in weeks from SRS to death)
时间窗: Post-SRS
次要结局
- Measures of ADC, rCBV, MTT and ktrans will be performed for each treated tumor at treatment and at 6 months following SRS(6 months post SRS)
- Time to progression (in weeks) will be measured for each treated tumor(Post-SRS)
- Diagnosis of progression or radiation necrosis (made on clinical reflection at study's end) will be determined for tumors where diagnosis is in question at 6 and 12 months after SRS(12 months post-SRS)