Comparison of Three Calcium Supplements

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Dietary Supplement: Calcium carbonate; Dietary Supplement: Placebo; Dietary Supplement: calcium phosphate; Dietary Supplement: Tricalcium Phosphate

• Registration Number: NCT03286673
• Lead Sponsor: University of Jena

Brief Summary

The study was conducted to investigate the metabolic effects of three different calcium compounds in healthy adults.

Detailed Description

Not available

Study Timeline

• Study Start: 2006-10
• Primary Completion: 2007-03
• Study Completion: 2007-03
• Status Verified: 2017-09
• Study First Submitted: 2017-09-11
• Study First Submitted QC: 2017-09-13
• Last Update Submitted: 2017-09-13
• Study First Posted: 2017-09-18
• Last Update Posted: 2017-09-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 31

Inclusion Criteria

• age 18 - 40 years

Exclusion Criteria

• diseases of the gastrointestinal tract
• pregnancy
• the intake of any medication (e. g. for thyroid gland)
• intake of dietary supplements

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Calcium carbonate	Calcium carbonate	Calcium carbonate (CaCO3) was incorporated in wholemeal and crispy wafer bread in order to achieve a additional calcium intake of 1000 mg/d.
Placebo	Placebo	Wholemeal and crispy wafer bread without additional calcium additive.
calcium phosphate	calcium phosphate	Pentacalcium hydroxy-triphosphate (Ca5(PO4)3OH) was incorporated in wholemeal and crispy wafer bread in order to achieve a additional calcium intake of 1000 mg/d.
Tricalcium Phosphate	Tricalcium Phosphate	β-tricalcium phosphate (Ca3(PO4)2) as incorporated in wholemeal and crispy wafer bread in order to achieve a additional calcium intake of 1000 mg/d.

Primary Outcome Measures

Name	Time	Method
Lipids in blood	after 4 weeks of each intervention	Lipids and lipoprotein concentration in serum.
Serum mineral concentration	after 4 weeks of each intervention	Calcium and Phosphate (and others) concentration in serum.
Stool mineral concentration	after 4 weeks of each intervention	Calcium and Phosphate concentration (and others) in stool from a three day stool collection
Sterols	after 4 weeks of each intervention	Neutrals sterols and bile acids in stool from a three day stool collection
Dietary intake	after 4 weeks of each intervention	Evaluation of the dietary intake using a three day weighed dietary record.
Urine mineral concentration	after 4 weeks of each intervention	Calcium and Phosphate concentration (and others) in urine from a three day urine collection