Effect of Squill Oxymel in Treatment of Knee Arthrosis

Phase 2

• Conditions: knee osteoarthritis.; Gonarthrosis

• Registration Number: IRCT2015101124474N1
• Lead Sponsor: Traditional Medicine College of Shahid Beheshti University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

Inclusion Criteria:
Age 40 to 80 years old that fill clinical and radiological criteria of ACR. after drug wash out,with VAS>40mm.
clinical and radiological criteria of ACR: knee pain + osteophite in radiography + at least 1 of 3 below criteria: age up 50 years old; morning stiffness less than 30 minutes; crepitation of knee.

Exclusion Criteria

history of rheumatoid arthritis and gout;
history of knee surgery;
patients with severe cardiovascular disease, including heart failure, advanced Class 3 and 4, sick sinus syndrome (SSS), 3rd degree atrioventricular block, Wolff Parkinson's White syndrome (WPW), ventricular tachycardia (VT), hypertrophic cardiomyopathy, aortic thoracic aneurysm;
proven malignancies;
GI bleeding(stomach bleeding);
severe liver disease(esophageal varices and bleeding, encephalopathy, ascites);
patients with Symptomatic gallstone(in history);
severe renal disease(creatinine greater than 3mg / dl);
joint injection of corticosteroids in the past three months;
received oral corticosteroids in the past 4 weeks;
oral or injectable NSAID in last seven days;
received chondrotin sulfate or glucosamine, warfarin, clopidogrel, digitalis, capsaicin, quinidine, laxatives or any other drugs, according to pharmacologists opinion;
pregnancy and Breast-feeding.
Exit criteria during study:
Not wanting to continue taking the drug by the patient for any reason;
Allergy symptoms or complications to acetaminophen or squill oxymel;
Any clinical condition that need to change a patient's treatment regimen.

Study & Design

• Study Type: interventional
• Study Design: Not specified