Looking at the Physiological Response of Ergometry in Critical Care Patients

Completed

• Conditions: Critical Ill Patients

• Registration Number: NCT04383171
• Lead Sponsor: University Hospital Southampton NHS Foundation Trust

Brief Summary

Exploring the physiological and metabolic demands of passive ergometry in the critical ill patient.

Detailed Description

This study explores the physiological and metabolic demands of passive ergometry as a step in active rehabilitation and compares two methods of monitoring these changes in critically ill patients.

Study Timeline

• Study Start: 2015-03-17
• Primary Completion: 2017-06-07
• Study Completion: 2017-06-07
• Status Verified: 2019-12
• Study First Submitted: 2019-12-11
• Study First Submitted QC: 2020-05-06
• Last Update Submitted: 2020-05-06
• Study First Posted: 2020-05-12
• Last Update Posted: 2020-05-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Physiological demands of early passive ergometry use in the critically ill patient.	These were taken every 10 minutes over the 60 minute data collection period.	Paired venous and arterial blood gas samples were collected.
Physiological demandsof early passive ergometry use in the critically ill patient.	Minute by minute measurements were taken over the 60 minute data collection period.	Respiratory measurements collected were stroke volume (SV m/L).

Secondary Outcome Measures

Name	Time	Method
Comparing two methods of measuring oxygen uptake (VO2 mL/min) and oxygen delivery (DO2 mL/min) during one passive ergometry session in the critically ill patient.	Minute by minute haemodynamic and metabolic measurements were taken over the 60 minute data collection period. Paired venous and arterial blood gas samples were taken every 10 minutes over the 60 minute data collection period.	Oxygen uptake (VO2) was calculated by two methods.; 1. Method one calculated VO2 with the value of CO from the LiDCO™ using the modified technique of the Fick equation using paired central mixed venous and arterial blood gas samples: VO2 mL/min = CO x (CaO2 - CvO2) x10.; 2. Method two calculated VO2 by the E-COVX metabolic module via the ventilator from the value of fraction of inspired O2 (FiO2), expiratory minute volume (MV), expired concentrations of O2 (FeO2) and CO2 (FeCO2) using the equation: VO2 ml/min= MV (FiO2 -FeO2 - FiO2 (FeCO2))/1-FiO2.