The effects of antithymocyte globulin (ATG) on the endothelial glycocalyx in kidney transplant recipients
- Conditions
- endothelial glycocalyx and atherosclerosis1000321610038430
- Registration Number
- NL-OMON34735
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 6
Inclusion Criteria
Female or male, age between 18 and 70 years
Kidney transplant recipient
ATG therapy because of an allograft rejection
Given written informed consent
Exclusion Criteria
Smoking
Diabetes Mellitus
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The thickness of the endothelial glycocalyx in kidney transplant recipients<br /><br>before and after ATG therapy. </p><br>
- Secondary Outcome Measures
Name Time Method <p>The following parameters will be measured:<br /><br><br /><br>- Glycocalyx constituents and glycocalyx regulating enzymes: hyaluronan,<br /><br>heparan sulfate, syndican-1, hyaluronidase en heparanase<br /><br>- IL-6, CRP</p><br>