Correlation between glucose variability evaluated by CGMS and labile hemoglobin A1c measured by high performance liquid chromatography (HPLC) in Japanese patients with diabetes.
- Conditions
- diabetes
- Registration Number
- JPRN-UMIN000030696
- Lead Sponsor
- St. Marianna University School of Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 100
Not provided
Patients who fall into any of the following criteria are unable to participate in the study. 1)patients who are considered to be ineligible for the study by the attending doctor,2)sever renal dysfunction(estimated glomerular filtration rate<45mL/min/1.73m2) or nephrotic syndrome,3)high blood urea nitrogen(>50mg/dL),4)hyper splenism about hemorrhage, hemolytic anemia, liver cirrhosis, 5)iron deficient anemia or being treated with iron, 6) a history of splenectomy, 7)being treated with antiplatelet agent about aspirin, 8)being treated with supplement contain vitamin C, 9)abnormal hemoglobinemia, 10)acute metabolic disturbance(diabetic ketoacidosis, hyperosmolar hyperglycemic syndrome, lactic acidosis, hypoglycemia) or sick day.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To calculate the coefficient and 95% interval(CI) between the values of labile HbA1c measured by HPLC and standard deviation (SD) of 24-hr glucose concentration measured by CGM prior to evaluate labile HbA1c.
- Secondary Outcome Measures
Name Time Method To calculate the coefficient and 95% interval(CI) between the values of labile HbA1c and mean glucose level or mean amplitude of glycemic excursions(MAGE).