EVALUATE THE EFFECT OF USE OF TRIIDOTHYRONINE T3 HORMONE TABLET IN CHILDREN UNDERGOING HEART SURGERIES.

Phase 4

Not yet recruiting

Conditions: Other secondary pulmonary hypertension,

Registration Number: CTRI/2021/03/032122

Lead Sponsor: Department of Cardiac Anaesthesia

Brief Summary: Cardiopulmonary Bypass(CPB) causes disruption of normalhomeostatic mechanisms and leads to various effects on different organ systems. Thyroid functions are also deranged by CPB leading to transient secondary hypothyroidism and sick euthyroid syndrome. We hypothesised that giving oral triido thyronine will decrease the ionotropic requirement and helpin enchancement of postoperativerecovery.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 80

Inclusion Criteria

all children less than 1 year of age undergoing complex cardiac surgeries like arterial switch operation, vsd with PAH, TAPVC repair under CPB.

Exclusion Criteria

Children who have history of radiation therapy, abnormal baseline thyroid function, thyroid diseases and other endocrine diseases, preoperative thyroid hormone therapy, use of drugs affecting thyroid function, and preoperative use of inotropic drugs for circulatory support, serum level of creatinine >2.0mg/dL downs syndrome mortality during study will be excluded from the study.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To assess the effect of Triidothyronine therapy on ionotropic requirement (mean ionotropic scores on 3rd postoperative day) in post complex congenital cardiac surgery under cardiopulmonary bypass	3rd postop day

Secondary Outcome Measures

Name	Time	Method
1. To compare Thyroid hormone profile.	2.To compare left ventricular function by assessing Left ventricular outflow tract velocity time integral(LVOT VTi), Ejection by echo

Trial Locations

Locations (1): PGIMER
🇮🇳
Chandigarh, CHANDIGARH, India
PGIMER
🇮🇳Chandigarh, CHANDIGARH, India
sujithareddy karri
Principal investigator
09493843921
sujithakarri@gmail.com