Screening of Specific Genes for Pigmented Villous Nodular Synovitis

Completed

• Conditions: Pigmented Villonodular Synovitis

• Registration Number: NCT04955535
• Lead Sponsor: Peking University Third Hospital

Brief Summary

This study retrospectively analyzed the history of present illness of PVNS patients in our hospital. The enrolled patients were followed up by telephone to follow up their postoperative recovery and living conditions. Take the patient's pathological specimens for immunohistochemical testing, evaluate the relationship between the expression of different molecular targets, clinical manifestations and patient prognosis, and explore new molecular targets related to disease diagnosis and treatment.

Detailed Description

This study retrospectively analyzed the symptoms, time of onset, injury history, laboratory examinations, imaging examinations, and intraoperative conditions of PVNS patients in our hospital. The enrolled patients were followed up by telephone to follow up their postoperative recovery and living conditions (VAS score, SF-36 score). Take the patient's pathological specimens for immunohistochemical testing, evaluate the relationship between the expression of different molecular targets, clinical manifestations and patient prognosis, and explore new molecular targets related to disease diagnosis and treatment.

Study Timeline

• Study Start: 2020-08-03
• Primary Completion: 2020-12-27
• Study Completion: 2020-12-27
• Status Verified: 2021-06
• Study First Submitted: 2021-06-25
• Study First Submitted QC: 2021-07-07
• Last Update Submitted: 2021-07-07
• Study First Posted: 2021-07-08
• Last Update Posted: 2021-07-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

1. Clinical diagnosis of pigmented villonodular synovitis.
2. Clinical diagnosis of giant cell tumor of tendon sheath

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Exclusion Criteria

1. No surgical treatment.
2. There were no pathological specimens during the operation.
3. The age of the patient is less than 18 years old or more than 60 years old.
4. The operation record shows nodular type.

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Difference of Visual Analog Score for pain between IL-1B immunohistochemistry positive group and negative group	One week after surgery	Difference of Visual Analog Score for pain between IL-1B immunohistochemistry positive group and negative group
Difference of SF-36 score between IL-1B immunohistochemistry positive group and negative group	One week after surgery	Difference of SF-36 score between IL-1B immunohistochemistry positive group and negative group
Difference of Visual Analog Score for pain between TNF-α immunohistochemistry positive group and negative group	One week after surgery	Difference of Visual Analog Score for pain between TNF-α immunohistochemistry positive group and negative group
Difference of scale score between immunohistochemistry positive group and negative group	One week after surgery	Difference of Visual Analog Score for pain between CSF-1 immunohistochemistry positive group and negative group
Difference of SF-36 score between CSF-1 immunohistochemistry positive group and negative group	One week after surgery	Difference of SF-36 score between CSF-1 immunohistochemistry positive group and negative group
Difference of SF-36 score between TNF-α immunohistochemistry positive group and negative group	One week after surgery	Difference of SF-36 score between TNF-α immunohistochemistry positive group and negative group

Secondary Outcome Measures

Name	Time	Method
Correlation between basic demographic characteristics and scale scores	One week after surgery	Correlation between age, gender and scale score

Trial Locations

Locations (1)

Institute of Sports Medicine, Peking University Third Hospital, Beijing Key Laboratory of Sports Injuries， Beijing, China; 🇨🇳 Beijing, Beijing, China