Real-time Monitoring of Motor Cortical Activity Induced by Low-frequency Repetitive Transcranial Magnetic Stimulation: Functional Near Infrared Spectroscopic Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Healthy
- Sponsor
- Samsung Medical Center
- Enrollment
- 10
- Locations
- 1
- Primary Endpoint
- Changes of Cortical activation
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
In this study, we investigated the effect of low-frequency repetitive trans cranial magnetic stimulation, one of the noninvasive brain stimuli, on the functional changes of the bilateral motor cortical activity in normal subjects using functional near infrared spectroscopy (fNIRS).
Detailed Description
In normal subjects, 1. the effect of low-frequency repetitive transcranial magnetic stimulation on cerebral cortex are measured in real time using fNIRS. 2. Changes in cerebral cortical activity before and after stimulation are measured using the motor function test and the motor-induced potential test
Investigators
Yun-Hee Kim
Professor, MD, PhD
Samsung Medical Center
Eligibility Criteria
Inclusion Criteria
- •Healthy adult men and women without history of central nervous system disease and abnormalities
Exclusion Criteria
- •Under 18 years old, 70 years old or older
- •A person who has inserted a metal object in a skull
- •A person with complete occlusion of the carotid artery
- •A person with epilepsy
- •Pregnant and lactating women
- •Who is not eligible for the test
Outcomes
Primary Outcomes
Changes of Cortical activation
Time Frame: Baseline and after intervention[Immediately after 20 minutes of intervention]
Cortical activation is measured by functional Near-Infrared-Spectroscopy (fNIRS) (NIRScout, NIRx, Germany) before and after stimulation
Secondary Outcomes
- changes in nine hole peg test(Baseline and after intervention[Immediately after 20 minutes of intervention])
- Sequential motor task(Baseline and after intervention[Immediately after 20 minutes of intervention])
- Changes in motor evoked potentia(Baseline and after intervention[Immediately after 20 minutes of intervention])