Detoxification From the Lipid Tract
- Conditions
- COVID-19 Vaccine Adverse Reaction
- Interventions
- Device: electroencephalogram biofeedbackDevice: electrical brain stimulationDevice: ultra-low frequency transcranial magnetic stimulation
- Registration Number
- NCT06357104
- Lead Sponsor
- Pachankis, Yang I., M.D.
- Brief Summary
Apart from electroencephalogram biofeedback and electrical brain stimulation adopted for maintenance treatment, the study utilizes ultra-low frequency transcranial magnetic stimulation (ULF-TMS) for initial γ-aminobutyric acid (GABA) stimulation. The cocktail therapy starts after the primary efficacy endpoint, and concomitant therapy is adopted throughout the study.
- Detailed Description
It was tested that GABA, in the joint action with topiramate, modulates macrophage activities by modulating cholesterol-metabolism associated molecules. GABA A receptors exhibit highly dynamic trafficking and cell surface mobility and influence on post-endocytic effects. Benzodiazepines (BZDs) exercise the mechanism of action by facilitating the binding of the inhibitory neurotransmitter GABA at various GABA receptors throughout the central nervous system (CNS). Alprazolam, a type of BZD, was tested by Al-Tubuly, Aburawi, Alghzewi, Gorash and Errwami in joint action with water-soluble beta blocker atenolol, in comparison with the non-selective β-adrenoceptor antagonist propranolol on the pharmacological effects on depression. The study hypothesizes that by replacing the water-soluble beta blocker to lipid-soluble one metoprolol, the effect of detoxification from the lipid and sebaceous immunobiological pathways can be achieved by the clathrin-dependent endocytosis process.
Even though partial progress was made in the NCT05839236 trial by statin therapies, the therapeutic effects have not been lasting nor significant. The study develops from the previous protocol for a cocktail therapy by the joint mechanism of actions of alprazolam, metoprolol, and pravastatin sodium for the detoxification process.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 1
- People who received full doses of COVID-19 vaccines.
- Women during pregnancy.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description GABA Cocktail electroencephalogram biofeedback - GABA Cocktail electrical brain stimulation - GABA Cocktail ultra-low frequency transcranial magnetic stimulation - GABA Cocktail Sertraline Hydrochloride - GABA Cocktail Clonazepam - GABA Cocktail Pravastatin Sodium 20 MG - GABA Cocktail Sacubitril Valsartan Sodium Hydrate - GABA Cocktail Alprazolam - GABA Cocktail Olanzapine - GABA Cocktail Metoprolol -
- Primary Outcome Measures
Name Time Method Changes in Leukocyte and Components' Quantities 24 days All white blood cells are evaluated.
Changes in Leukocyte Components' Ratios 24 days All white blood cells are evaluated.
Quantity Changes in Megakaryocyte-Erythroid Progenitor 24 days Changes in Hemoglobin Distribution 24 days Changes in Mean Corpuscular Hemoglobin 24 days Changes in Hematocrit 24 days Changes in Plateletcrit 24 days Red cell Distribution Width Coefficient of Variation 24 days Changes in Particulate Matter Sizes 24 days Changes in Total Lipid Quantities 24 days Changes in Apolipoproteina 24 days Changes in Lipoprotein (a) 24 days
- Secondary Outcome Measures
Name Time Method Heart Rate Changes 24 days Heart rate changes before and after medication each day.
Blood Pressure Changes 24 days Recorded systolic and diastolic blood pressures' changes before and after medication each day.
Trial Locations
- Locations (1)
Residential Address
🇨🇳Chongqing, Chongqing, China