Detoxification From the Lipid Tract

Phase 4

Completed

• Conditions: COVID-19 Vaccine Adverse Reaction
• Interventions: Device: electroencephalogram biofeedback; Device: electrical brain stimulation; Device: ultra-low frequency transcranial magnetic stimulation; Drug: Sertraline Hydrochloride; Drug: Clonazepam; Drug: Alprazolam; Drug: Metoprolol; Drug: Olanzapine; Drug: Pravastatin Sodium 20 MG; Drug: Sacubitril Valsartan Sodium Hydrate

• Registration Number: NCT06357104
• Lead Sponsor: Pachankis, Yang I., M.D.

Brief Summary

Apart from electroencephalogram biofeedback and electrical brain stimulation adopted for maintenance treatment, the study utilizes ultra-low frequency transcranial magnetic stimulation (ULF-TMS) for initial γ-aminobutyric acid (GABA) stimulation. The cocktail therapy starts after the primary efficacy endpoint, and concomitant therapy is adopted throughout th...

Detailed Description

It was tested that GABA, in the joint action with topiramate, modulates macrophage activities by modulating cholesterol-metabolism associated molecules. GABA A receptors exhibit highly dynamic trafficking and cell surface mobility and influence on post-endocytic effects. Benzodiazepines (BZDs) exercise the mechanism of action by facilitating the binding of t...

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2024-02-26
• Study First Submitted: 2024-03-10
• Primary Completion: 2024-03-14
• Study Completion: 2024-03-20
• Status Verified: 2024-04
• Study First Submitted QC: 2024-04-03
• Last Update Submitted: 2024-04-03
• Study First Posted: 2024-04-10
• Last Update Posted: 2024-04-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1

Inclusion Criteria

• People who received full doses of COVID-19 vaccines.

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Exclusion Criteria

• Women during pregnancy.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
GABA Cocktail	electroencephalogram biofeedback	-
GABA Cocktail	electrical brain stimulation	-
GABA Cocktail	ultra-low frequency transcranial magnetic stimulation	-
GABA Cocktail	Sertraline Hydrochloride	-
GABA Cocktail	Clonazepam	-
GABA Cocktail	Pravastatin Sodium 20 MG	-
GABA Cocktail	Sacubitril Valsartan Sodium Hydrate	-
GABA Cocktail	Alprazolam	-
GABA Cocktail	Olanzapine	-
GABA Cocktail	Metoprolol	-

Primary Outcome Measures

Name	Time	Method
Changes in Leukocyte and Components' Quantities	24 days	All white blood cells are evaluated.
Changes in Leukocyte Components' Ratios	24 days	All white blood cells are evaluated.
Quantity Changes in Megakaryocyte-Erythroid Progenitor	24 days
Changes in Hemoglobin Distribution	24 days
Changes in Mean Corpuscular Hemoglobin	24 days
Changes in Hematocrit	24 days
Changes in Plateletcrit	24 days
Red cell Distribution Width Coefficient of Variation	24 days
Changes in Particulate Matter Sizes	24 days
Changes in Total Lipid Quantities	24 days
Changes in Apolipoproteina	24 days
Changes in Lipoprotein (a)	24 days

Secondary Outcome Measures

Name	Time	Method
Heart Rate Changes	24 days	Heart rate changes before and after medication each day.
Blood Pressure Changes	24 days	Recorded systolic and diastolic blood pressures' changes before and after medication each day.

Trial Locations

Locations (1)

Residential Address; 🇨🇳 Chongqing, Chongqing, China