TO COMPARE TWO TECHNIQUES OF TOTAL KNEE REPLACEMENT WITH RESPECT TO AFFECT ON HEART AND LUNGS
Phase 4
Completed
- Conditions
- Health Condition 1: null- Patients undergoing total knee replacement
- Registration Number
- CTRI/2014/01/004291
- Lead Sponsor
- All India Institute of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 56
Inclusion Criteria
Adult patient with sufficient knee pathology to be appropriate candidate for Total knee replacement falling in ASA 1 and 2 groups.
Exclusion Criteria
1.Simultaneous hip and knee arthroplasty
2.Simultaneous bilateral TKR
3.Morbid obesity BMI > 40
4.Esophageal disease
5.History of DVT/ PE/ prolonged immobilization
6.Patients requiring a tibial / femoral stem
7.Refusal to give consent
8.Patients done under regional anesthesia
9.Patients having any bleeding diathesis or on anticoagulants
10.Patients suffering from renal disease precluding the use of enoxaparin
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.Embolus burden quantified by TEE at time of intramedullary rod insertion and after tourniquet release <br/ ><br>2.Relation of embolic showers with pulmonary artery wedge pressure <br/ ><br>3.Bone marrow/ fat/ thrombus/ air/ cement components in blood samples <br/ ><br>4.Measured and hidden Blood loss <br/ ><br>5.Operating time <br/ ><br>Timepoint: 1. At baseline <br/ ><br>2. After bone cuts <br/ ><br>3. After trial <br/ ><br>4. After cementing <br/ ><br>5. After tourniquet release
- Secondary Outcome Measures
Name Time Method 1. Relation of embolic showers with pulmonary artery wedge pressure <br/ ><br>2. Bone marrow/ fat/ thrombus/ air/ cement components in blood samples <br/ ><br>3. Measured and hidden Blood loss <br/ ><br>4. Operating time <br/ ><br>Timepoint: At baseline <br/ ><br>2. After bone cuts <br/ ><br>3. After trial <br/ ><br>4. After cementing <br/ ><br>5. After tourniquet release