Gait Control in Parkinson Disease

Recruiting

• Conditions: Parkinson Disease
• Interventions: Other: Walking test; Other: Disease assessement

• Registration Number: NCT05908279
• Lead Sponsor: Université Catholique de Louvain

Brief Summary

Previous work has shown that a statistical property of gait characterised by long-range autocorrelation functions is altered in Parkinson disease (PD). On the other hand it has been suggested that the same property is linked to the ability in healthy humans to co-regulate the amplitude and cadence of strides towards maintaining a constant speed. Here the investigators want to better understand why it is altered in PD by measuring the transitions between gait instructed by a metronome, and gait without metronome. The experimental conditions will allow the comparisons between these transitions across PD and healthy groups of volunteers, and assess differences based on statistical and computational modelling. The link with potential freezing episodes will also be studied to assess whether the statistical determinants of gait control in this population can be used as a proxy or predictor of the occurence of freezing episodes.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-05-01
• Study First Submitted: 2023-05-25
• Status Verified: 2023-06
• Study First Submitted QC: 2023-06-08
• Last Update Submitted: 2023-06-08
• Study First Posted: 2023-06-18
• Last Update Posted: 2023-06-18
• Primary Completion: 2027-10-31
• Study Completion: 2027-10-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Patients and volunteers able to walk for 20mins and without other neurological disorders.

Exclusion Criteria

• Patients or volunteers unable to walk for 20mins and with other neurological disorders.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
PD	Disease assessement	Patients with Parkinson's disease
PD	Walking test	Patients with Parkinson's disease
Control	Walking test	Healthy volunteers

Primary Outcome Measures

Name	Time	Method
Stride cadence	Measured during the entire experiment (an average of 4.5 years)	Time between two consecutive heel strikes. Units are seconds.
Stride amplitude	Measured during the entire experiment (an average of 4.5 years)	Distance between two consecutive heel strikes. Units are meters.

Trial Locations

Locations (1)

Université catholique de Louvain; 🇧🇪 Louvain-la-Neuve, Belgium