Pre-Administration of 6% Hydroxyethyl Starch For Reduction of Pain on Propofol Injection: A Placebo Controlled Randomised Study

After thorough preoperative assessment of each patient, written informed consent will be taken. on arrival in the operating room, an 18 G cannula is inserted. No analgesic premedication will be given. The study drug HES/ NS will be drawn up in two 50 ml syrings and administer it over three to 5 minutes.once the 100 ml bolus is over, all patients will be premedicated with inj.glycopyrolate 0.004mg/ kg if and inj. Tramadol 2 mg/ kg if.Preoxygenation will be done with 100% O2 for 3 minutes. Induction will be done using inj. Propofol 1.2 to 2.5 mg/kg if administered till loss of verbal contact. During propofol injection pain will be assessed Evert 5 to 10 seconds before the loss of verbal contact as 0- no pain, 1-mild pain,2- moderate and 3 - severe using Mc Crimick and hunter scale, tracheal intubation will be facilitated with inj.succinylscholine 2mg/ kg.Trachea will be intubated. General anaesthesia will be maintained with oxygen , inj atracurium and supplemented with inhalational sevoflurane.Routine ASA monitoring will be established. The vital parameters will be recorded. All patients will be asked to recall if there was pain during injection of propofol in the recovery room and incidence of pain was graded as no recall of pain present.