MRI measurement of the effects of moderate versus deep neuromuscular blockade on the abdominal working space during laparoscopic surgery in a prospective cohort study.

Phase 4

Completed

• Conditions: laparoscopy; living donor nephrectomy; 10038430; 10038365

• Registration Number: NL-OMON48996
• Lead Sponsor: Radboud Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 10

Inclusion Criteria

- all adult patients (18 years or older) scheduled for laparoscopic donor nephrectomy
- obtained informed consent

Exclusion Criteria

* Unable to provide informed consent
* known or suspect allergy to mivacurium, rocuronium or sugammadex
* neuromuscular disease
* indication for rapid sequence induction
* Being unable to undergo MRI due to any reason (e.g. non MRI-compatible implants, epilepsy)
* Deficiency of vitamin K-dependent clotting factors, coagulopathy or active use of coumarin derivates.
* Peri-operative use of fusidic acid or flucloxacilline
* Severe renal impairment (creatinine clearance <30ml/min)
* BMI> 30 kg/m2
* ASA-score > 2

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The abdominal working space space measured by MRI: Skin - sacral promontory<br /><br>distance</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The abdominal working space space measured by MRI: 3D volume of the abdominal<br /><br>cavity</p><br>