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临床试验/CTRI/2024/07/069853
CTRI/2024/07/069853招募中3 期

Comparative Evaluation Of Mouth Rinsing With Probiotic Herbal And Chlorhexidine Mouthwash On Salivary pH Of Children- A Randomized Control Trial

Dr Rasika Talmale1 个研究点 分布在 1 个国家目标入组 36 人开始时间: 2024年8月16日最近更新:
适应症
相关药物

试验速览

阶段
3 期
状态
招募中
发起方
入组人数
36
试验地点
1
主要终点
Reduction in Salivary pH Score.

研究概览

简要总结

The maintenance of oral hygiene is one of the key elements of oral health. The oral cavity harbors bacteria and is exposed to environmental stimuli such as foods, chemicals, and temperature which remain in a balanced state during healthy state of mouth. However, imbalances in equilibrium of defense mechanisms and various stimuli lead to various oral diseases such as dental caries and periodontal diseases. Salivary pH has a direct effect in maintaining oral health. Acidic pH results in demineralization and gingival inflammation. Mouth rinsing results in clearance of debris and prevents accumulation of harmful bacteria, thereby promoting oral health. Saliva is a dynamic system which helps to maintain a balance of the carious process by various variables such as pH from a salivary fluid and buffer capacity. Salivary pH is a good indicator of demineralization which is the first step in the carious process. They are non-sterile aqueous solutions and used as an antibacterial agent which prevents the growth of bacteria in the mouth and teeth and for decreasing oral malodor. They are commonly used as topical solutions against plaque development, and also can be used frequently to prevent oral infections. Mouthwash supplements routine mechanical oral hygiene procedures in controlling supragingival plaque formation. Natural herbs when used in mouthwashes, have shown significant advantages over the chemical ones. Probiotics, another potential tool of anti-plaque activity, have been reported to have beneficial effects on oral health. Hence, the present study was designed with an aim to compare the effectiveness of herbal and probiotic mouthwashes with that of chlorhexidine (CHX) on salivary pH.

研究设计

研究类型
Interventional
分配方式
Other
盲法
Participant and Outcome Assessor Blinded

入排标准

年龄范围
6.00 Year(s) 至 11.00 Year(s)(—)
性别
All

入选标准

  • •Free from any systemic illness.
  • •Children with informed consent.

排除标准

  • •Children with periodontal diseases.
  • •Children taken antibiotic within one month before the study.
  • •Children with any congenital anomalies, physical or mental disabilities.
  • •Children with any severe medical illness or allergy to any of the content of mouthwash.

结局指标

主要结局

Reduction in Salivary pH Score.

时间窗: O(BASELINE), 1 WEEK

次要结局

  • To compare the efficacy of Probiotic, Herbal and Chlorhexidine(mouthwash on salivary pH of children of 6 to 11 years.)

研究者

发起方
Dr Rasika Talmale
申办方类型
Other [[Self Funded]]
责任方
Principal Investigator
主要研究者

Dr Rasika Talmale

Chhattisgarh Dental College And Research Institute, Rajnandgaon.

研究点 (1)

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