Effects of Continuous Passive Motion on the Spinal Circuitries and Its Adaptation in Patients With Spasticity Resulting From Upper Motor Neuron Lesions

Not Applicable

Completed

• Conditions: Spinal Cord Injury(SCI)
• Interventions: Procedure: Ankle continuous passive motion machine.

• Registration Number: NCT02122276
• Lead Sponsor: Chang Gung University

Brief Summary

In animal and human studies, histochemical and physiological evidences showed that the muscle transferred from slow, fatigue-resistant muscle to fast, fatigable muscle after spinal cord injury. The alternation of muscular property was accompanied by the alternation of spinal circuitry property, and was related to the immobilization adaptation. Previous study showed that remobilization by continuous passive motion (CPM) for one month would restore the function of spinal circuitry in individual with chronic SCI. It is possible that long term application of CPM can reverse the adaptation of contractile properties of the paralyzed muscle after SCI. The purpose of this study is to investigate the effect of a four month CPM training on muscular properties in individuals with chronic SCI.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-01
• Primary Completion: 2012-01
• Study Completion: 2012-01
• Status Verified: 2014-04
• Study First Submitted: 2014-04-17
• Study First Submitted QC: 2014-04-23
• Last Update Submitted: 2014-04-23
• Study First Posted: 2014-04-24
• Last Update Posted: 2014-04-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 7

Inclusion Criteria

• Clinical diagnosis of complete spinal cord injury

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
SCI	Ankle continuous passive motion machine.	SCI participated in a 4-month robot-assisted passive ankle exercise regimen.

Primary Outcome Measures

Name	Time	Method
Clinical muscle tone tests	Baseline, 1 month, 2 months, 3 months, and 4 months	Measure of changes in clinical muscle tone tests of soleus and tibialis anterior by Modified Ashworth Scale.
The contractile properties of the muscles	Baseline, 1 month, 2 months, 3 months, and 4 months	Measure of changes in contractile properties of soleus and tibialis anterior
Fatigue index	Baseline, 1 month, 2 months, 3 months, and 4 months	Measure of changes in Fatigue index of soleus and tibialis anterior.
Patient Reported Impact of Spasticity Measure (PRISM)	Baseline, 1 month, 2 months, 3 months, and 4 months	Measure of changes in PRISM.
The potential adverse effects of ankle swelling	Baseline, 1 month, 2 months, 3 months, and 4 months	Measure of changes in the potential adverse effects of ankle swelling.

Trial Locations

Locations (1)

Chang Gung University; 🇨🇳 Taoyuan, Taiwan