Effect of Cisatracurium Versus Atracurium on Intraocular Pressure in Patients Underwent General Anesthesia

Phase 2

Completed

• Conditions: Intraocular Pressure
• Interventions: Drug: cisatracurium; Drug: atracurium

• Registration Number: NCT01273831
• Lead Sponsor: Isfahan University of Medical Sciences

Brief Summary

The purpose of this study is to determine which drug makes lower intraocular pressure

Detailed Description

Increase in intraocular pressure (IOP) following tracheal intubation during general anesthesia can be troublesome. The investigators compared the influence of cisatracurium and atracurium on IOP in patients undergoing general anesthesia.

Study Timeline

• Status Verified: 2009-07
• Study Start: 2009-07
• Primary Completion: 2009-12
• Study Completion: 2009-12
• Study First Submitted: 2011-01-10
• Study First Submitted QC: 2011-01-10
• Last Update Submitted: 2011-01-10
• Study First Posted: 2011-01-11
• Last Update Posted: 2011-01-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

ASA class of I or II baseline IOP of lower than 20 mmHg stable hemodynamics no history of ophthalmic diseases not using drugs affecting IOP (e.g. anticholinergics, sympathomimetics) no contraindication for atracurium or cisatracurium administration.

Exclusion Criteria

difficulty in mask ventilation or in tracheal intubation end expiratory CO2 of below 35 mmHg or over 45 mmHg O2 saturation of below 90%

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
cisatracurium	cisatracurium	Patients who underwent general anesthesia received cisatracurium
atracurium	atracurium	Patients who underwent general anesthesia received atracurium

Primary Outcome Measures

Name	Time	Method
intraocular pressure	at 2 minutes after intubation	determining intraocular pressure in atracurium and cisatracurium groups

Secondary Outcome Measures

Name	Time	Method
systolic blood pressure	at 2 minutes after intubation	identification of systolic blood pressure in atracurium and cisatracurium groups

Trial Locations

Locations (1)

Al-zahra university hospital; 🇮🇷 Isfahan, Iran, Islamic Republic of