APA and PAS Training for Gait Initiation in Parkinson's Disease
- Conditions
- Parkinson Disease
- Interventions
- Other: Weight shift training and APA feedbackProcedure: Paired associative stimulation
- Registration Number
- NCT06363071
- Lead Sponsor
- Chang Gung University
- Brief Summary
Our research focused on understanding the interplay between brain excitability and balance function in patients with Parkinson's disease (PD), alongside evaluating effective physical therapy methods. It highlights the prevalence of non-motor disorders and cognitive impairments among PD patients, including balance and postural issues, cognitive function decline, and gait instability. Additionally, it notes that PD patients exhibit abnormal electrophysiological responses, indicating altered central excitability.
- Detailed Description
Research on Brain Excitability and Balance Function Performance in Patients with Parkinson's Disease and Related Physical Therapy Methods
Research indicates that non-motor disorders and cognitive impairments are prevalent in most patients with Parkinson's disease. These include balance issues, postural instability, impaired cognitive functions like working memory and executive functions, and gait instability. Additionally, electrophysiological phenomena in Parkinson's disease patients reveal abnormal central excitatory and inhibitory responses compared to healthy individuals.
This experiment seeks to investigate the link between motor performance and brain excitability in patients with Parkinson's disease. Previous studies suggest that associative electrical stimulation, used to regulate sensorimotor information integration, can enhance brain excitability in both healthy individuals and those with Parkinson's disease. However, the optimal parameters for this stimulation remain uncertain.
Furthermore, balance exercise training can improve motor performance in Parkinson's disease patients. This study aims to determine if various designs of associative electrical stimulation parameters can help these patients achieve optimal brain excitability regulation. The combined approach of this stimulation and balance exercise training aims to maintain and improve the patients' functional performance, thereby enhancing the safety of their daily activities.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 100
- Clinical diagnosis of Parkinson disease.
- Musculoskeletal injuries on legs
- Osteoporosis.
- Any peripheral or central nervous system injury or disease patients.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Stage 3: PD APA training group Weight shift training and APA feedback Weight shift training and APA feedback. Stage 1:Healthy people Paired associative stimulation To establish PAS baseline and reliability. Stage 2:PD people Paired associative stimulation To establish stage 3 training protocol. Stage 3:PD PAS group Paired associative stimulation Using PAS to regulate brain plasticity
- Primary Outcome Measures
Name Time Method Balance Performance Baseline, 4 weeks and 8 weeks. Measured by the duration the stance can be maintained. Unit：seconds(s)
COP Path Length in Balance Tasks Baseline, 4 weeks and 8 weeks. The total distance traveled by the COP over a specified period. Longer path lengths can indicate increased effort to maintain balance or greater instability. Unit：millimeters(mm)
Step Time Baseline, 4 weeks and 8 weeks. The duration taken for one complete step, measuring from foot-off of one foot to the next foot-off of the same foot, usually expressed in seconds.
COP Displacement in Balance Tasks Baseline, 4 weeks and 8 weeks. Measures of COP movement in the anterior-posterior (AP) and medial-lateral (ML) directions, offering insights into the directional tendencies of balance control. Unit：millimeters(mm)
Motor Evoked Potentials (MEPs) Baseline, 4 weeks and 8 weeks. MEPs are the electrical responses recorded from muscles following stimulation of the motor cortex. They reflect the efficiency of neural transmission from the cortex to the muscle. Unit：millivolts (mV)
Intracortical Inhibition (ICI) Baseline, 4 weeks and 8 weeks. ICI is measured similarly to ICF but with a shorter inter-stimulus interval (e.g., 1-5 ms), resulting in a suppressed MEP amplitude. This suppression reflects inhibitory processes within the cortex.
Step Length Baseline, 4 weeks and 8 weeks. The linear distance between the two ankles, typically expressed in centimeter(cm).
Intracortical Facilitation (ICF) Baseline, 4 weeks and 8 weeks. ICF is measured by applying a pair of TMS pulses with a short interval (e.g., 8-15 ms) where the first (subthreshold) pulse is followed by a second (suprathreshold) pulse, leading to an increased amplitude of the MEP.
Walking Speed Baseline, 4 weeks and 8 weeks. The time taken by participants to walk a standardized distance, typically expressed in centimeters per second (cm/s).
- Secondary Outcome Measures
Name Time Method Double Support Time Baseline, 4 weeks and 8 weeks. The portion of the gait cycle where both feet are in contact with the ground, indicating the transition phase between steps, expressed as a percentage of the gait cycle or in seconds.
COP Velocity in Balance Tasks Baseline, 4 weeks and 8 weeks. The speed at which the COP moves, calculated over the duration of the balance task. Higher velocities may reflect more dynamic balance adjustments or instability. Unit：millimeters per second(mm/s)
Swing Time Baseline, 4 weeks and 8 weeks. The portion of the gait cycle where the foot is not in contact with the ground, moving forward to the next step. It is usually expressed as a percentage of the total gait cycle or in seconds.
COP Area in Balance Tasks Baseline, 4 weeks and 8 weeks. The area covered by the COP trajectory during the balance task, providing an estimate of the sway envelope. A larger area might indicate poorer balance control. Unit：square millimeters(mm\^2)
Single Support Time Baseline, 4 weeks and 8 weeks. The duration within the gait cycle when only one foot is in contact with the ground, typically measured in seconds or as a percentage of the total gait cycle.
Stance Time Baseline, 4 weeks and 8 weeks. The portion of the gait cycle when the foot is in contact with the ground, supporting body weight. It's typically expressed as a percentage of the total gait cycle or in seconds
Cadence Baseline, 4 weeks and 8 weeks. The number of steps an individual takes per minute, providing an overview of gait speed and rhythm, , expressed as steps per minute.
Trial Locations
- Locations (1)
Chang Gung University
🇨🇳Taoyuan, Taiwan