Dermoscopic Monitoring of Pediatric Melanocytic Nevi Regarding Pattern and Diameter Changes

Completed

• Conditions: Nevus, Pigmented
• Interventions: Diagnostic Test: Videodermoscopy

• Registration Number: NCT05463510
• Lead Sponsor: Istanbul Training and Research Hospital

Brief Summary

Childhood and adolescence are a dynamic process in terms of nevogenesis, and the development and growth of new melanocytic nevus is frequently observed. Melanomas, although rare, can also be seen in the pediatric age group. Therefore, nevus monitoring with videodermoscopy may be necessary in the pediatric age group. Aim of our study is to show the dynamic pattern and diameter modifications in pediatric nevi.

Detailed Description

Aim of our study is to show the dynamic pattern and diameter modifications in pediatric nevi. Patients who applied to the Dermatology Clinic of Istanbul Training and Research Hospital between January 2008 and January 2022, were diagnosed with pediatric melanocytic nevus clinically and dermoscopically were included. Patients who had records for at least twice with videodermoscopy every 3 months were included. In the study, 301 pediatric melanocytic nevi belonging to 50 patients were evaluated.

The following characteristics were recorded in a database specifically designed for the study:Demographic findings of the patients, nevus localization, nevus pattern (baseline and follow-up), nevus diameter (base line and follow-up at 3/12/36th months), histopathological results of nevi that underwent total excision were recorded. The change in nevus diameter during follow-up was measured in millimeters based on the longest axis. Presence of peripheral globules, outcome of peripheral globules, characteristics of peripheral globules were recorded. Characteristics of peripheral globules were evaluated according to being around the entire lesion (circumferential) versus focally presence, typical (uniform shape and colors) and being regular (single rim of globules or multiple rim of globules)

Study Timeline

• Study Start: 2022-03-25
• Primary Completion: 2022-04-25
• Study Completion: 2022-04-25
• Status Verified: 2022-07
• Study First Submitted: 2022-07-08
• Study First Submitted QC: 2022-07-18
• Last Update Submitted: 2022-07-18
• Study First Posted: 2022-07-19
• Last Update Posted: 2022-07-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Subjects <18 years of age
• Subjects who have dermoscopic diagnosis of melanocytic nevus
• Subjects who had dermoscopic follow up for at least 3 months

Exclusion Criteria

• Subjects >18 years of age

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Pediatric melanocytic nevus	Videodermoscopy	50 patients and 301 pediatric nevi were evaluated

Primary Outcome Measures

Name	Time	Method
Pediatric nevi diameter change in millimeters	3-36 months	1.Nevus diameter change at 3/12/36th months (measurement of longest axis of nevus as millimeters with videodermoscopy)
Pediatric nevi pattern change	3-36 months	Nevus pattern change at 3/12/36th months (pattern is categorized as globular/reticular/homogenous/fibrillar/parallel furrow or combinations)
Presence of peripheral globules	3-36 months	Peripheral globules will be recorded if present and will be categorized as (increased, decreased or no change) at the 3/12/36th months

Trial Locations

Locations (1)

Istanbul Teaching and Research Hospital; 🇹🇷 Istanbul, Istanbul/Fatih, Turkey