Modification of Complications in Infertile Men with Varicocele by Curcumin Nanomicels

Not Applicable

Recruiting

• Conditions: Varicocele.; Scrotal varices; I86.1

• Registration Number: IRCT20170923036334N3
• Lead Sponsor: Iranian academic center for education culture and research

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 30 May 2022

Recruitment & Eligibility

• Status: Recruiting
• Sex: Male
• Target Recruitment: 100

Inclusion Criteria

Infertile Men with Varicocele

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Serum Levels of Sex Hormones. Timepoint: Before Taking the Drug and 10 Weeks After Taking the Drug. Method of measurement: Eliza Kit.;Sperm Parameters. Timepoint: Before Taking the Drug and 10 Weeks After Taking the Drug. Method of measurement: Standard Clinical Analysis of Semen for Evaluation of Sperm Parameters with The Usual Laboratory Method and Light Microscope According to the Organization CriteriaWHO-2010 World Health Takes Place.;Oxidative Stress Rate. Timepoint: Before Taking the Drug and 10 Weeks After Taking the Drug. Method of measurement: ROS Positive Sperms were Evaluated Using H2DCFDA (DCFH - DA: 2 ', 7'-dichlorodihydrofluoresceindiacetat) (Sigma Co., USA) and Analyzed by Flow Cytometry.

Secondary Outcome Measures

Name	Time	Method
Viability. Timepoint: Before Taking the Drug and 10 Weeks After Taking the Drug. Method of measurement: Viability is Assessed by Eosin-Nigrosin Staining and Examined Using a Light Microscope.;DNA Damage Assessment. Timepoint: Before Taking the Drug and 10 Weeks After Taking the Drug. Method of measurement: Tunnel Kit.;Measurement of Sperm Mitochondrial Activity. Timepoint: Before Taking the Drug and 10 Weeks After Taking the Drug. Method of measurement: Rhodamine Staining is Used to Assess the Mitochondrial Activity of Sperm.