Diagnostic Value of Antibodies Against Carbamylated Proteins in Psoriatic Arthritis.
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 300
- Locations
- 1
- Primary Endpoint
- Sensitivity of anti-carbamylated protein antibodies for the diagnosis of psoriatic arthritis in the psoriatic population
Study Overview
Brief Summary
Anti-carbamylated protein (anti-CarP) antibodies are present in approximately one-fourth of the patients who are seronegative for both rheumatoid factor and anti-citrullinated protein antibody and who may therefore have psoriatic arthritis. The investigators hypothesized that detection of anti-CarP antibodies in serum may be useful for diagnosis of psoriatic arthritis.
Study Design
- Study Type
- Interventional
- Allocation
- Non Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Diagnostic
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 70 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •"Controls" : Patients with a psoriasis confirmed by a dermatologist and with absence of psoriatic arthritis confirmed by a rheumatologist.
- •"Cases" : Patients with psoriatic arthritis fulfilling the classification criteria for psoriatic arthritis (CASPAR), with a diagnosis confirmed by a rheumatologist and associated with personal or familial psoriasis.
Exclusion Criteria
- •"Controls": Presence of any chronic rheumatic inflammatory disease such as psoriatic arthritis.
Arms & Interventions
Controls
Patients with psoriasis and without psoriatic arthritis.
Intervention: Serum anti-CarP antibodies detection (Diagnostic Test)
Cases
Patients with psoriatic arthritis and with personal or familial psoriasis.
Intervention: Serum anti-CarP antibodies detection (Diagnostic Test)
Outcomes
Primary Outcomes
Sensitivity of anti-carbamylated protein antibodies for the diagnosis of psoriatic arthritis in the psoriatic population
Time Frame: Anti-CarP antibodies will be assessed in the sera collected at the recruitment visit
Secondary Outcomes
No secondary outcomes reported