Prospective Urban Rural Epidemiology Study

Recruiting

• Conditions: Health Behavior; Cardiovascular Diseases; Environmental Exposure; Lung Diseases; Injuries; Communicable Disease; Risk Factor, Cardiovascular; Cancer; Renal Disease

• Registration Number: NCT03225586
• Lead Sponsor: Population Health Research Institute

Brief Summary

To examine the impact of health determinants at the individual (e.g. health related behaviors) and societal level (e.g. environmental factors, health related policy, quality of health systems) on health outcomes (e.g. death, non-communicable disease development) across a range of socioeconomic and health resource settings. Additional components of this study will examine genetic factors for non-communicable diseases. This will be examined both through a cross sectional component, and prospectively (cohort component).

Detailed Description

1. To examine the relationship between societal influences and prevalence of risk factors and chronic noncommunicable diseases. Societal determinants are measured by an index of measures from each of the 4 domains of interest: built environment, food and nutrition policy, psychosocial/socioeconomic factors, and tobacco.

2. To examine the relationship between societal determinants and incidence of chronic noncommunicable disease events (e.g. cardiovascular disease, cancer) and on changes in rates of selected risk factors (e.g. smoking)

3. To examine the relationship between health related behaviors (e.g. diet, physical activity, smoking, alcohol) and health outcomes (e.g. death, non-communicable diseases)

4. The quality of health systems across a diverse range of health resource settings, and how this impacts health outcomes

5. Genetic factors for non-communicable diseases

Study Timeline

• Study Start: 2002-01-01
• Study First Submitted: 2017-07-19
• Study First Submitted QC: 2017-07-19
• Study First Posted: 2017-07-21
• Status Verified: 2024-01
• Last Update Submitted: 2024-01-29
• Last Update Posted: 2024-01-31
• Primary Completion: 2030-12-31
• Study Completion: 2030-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 200000

Inclusion Criteria

• consenting adults between 35-70 years of age

Exclusion Criteria

• none

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
incident cardiovascular disease	mean follow up of 10 years	cardiovascular death, stroke, myocardial infarction, heart failure

Secondary Outcome Measures

Name	Time	Method
hypertension	mean follow up of 10 years	development of hypertension and changes in blood pressure
obesity	mean follow up of 10 years	development of obesity, change in BMI
incident cancer	mean follow up of 10 years	total and cause specific cancers
All Cause Hospitalizations	mean follow up of 10 years	All cause hospitalizations
All cause and cause specific mortality	mean follow up of 10 years	death from all causes, and cause specific deaths
Incident COPD	mean follow up of 10 years	development of COPD
Respiratory outcomes	mean follow up of 10 years	change in pulmonary function test
Kidney disease	mean follow up of 10 years	end stage renal disease, dialysis, transplant, changes in renal function
Incident Asthma	mean follow up of 10 years	development of asthma
Pneumonia	mean follow up of 10 years	hospitalization for pneumonia
incident diabetes	mean follow up of 10 years	development of diabetes
incident injuries	mean follow up of 10 years	assessing fatal and non-fatal injuries due road traffic accidents and falls

Trial Locations

Locations (34)

Dante Pazzanese Institute of Cardiology; 🇧🇷 São Paulo, Brazil

Isfahan University of Medical Sciences; 🇮🇷 Isfahan, Iran, Islamic Republic of

Research Institute of Cardiology & Internal Diseases; 🇰🇿 Almaty, Kazakhstan

Universiti Teknologi MARA, UCSI Universiti; 🇲🇾 Kuala Lumpur, Malaysia

Aga Khan University; 🇵🇰 Karachi, Pakistan

King Saud University; 🇸🇦 Riyadh, Saudi Arabia

Sahlgrenska University Hospital/Östra Hospital; 🇸🇪 Göteborg, Sweden

Fundacion Oftalmologica de Santander - FOSCAL; 🇨🇴 Floridablanca, Santander, Colombia

Université Laval Institut universitaire de cardiologie et de pneumologie de Québec; 🇨🇦 Quebec City, Quebec, Canada

St John's Research Institute; 🇮🇳 Bangalore, Karnataka, India

Simon Fraser University; 🇨🇦 Vancouver, British Columbia, Canada

Population Health Research Institute; 🇨🇦 Hamilton, Ontario, Canada

Independent University, Bangladesh; 🇧🇩 Dhaka, Bangladesh

Kyrgyz Society of Cardiology, National Center of Cardiology and Internal Disease; 🇰🇬 Bishkek, Kyrgyzstan

University Kebangsaan Malaysia; 🇲🇾 Kuala Lumpur, Malaysia

Wroclaw Medical University & Department of Internal Medicine; 🇵🇱 Wrocław, Poland

School of Public Health, University of the Western Cape; 🇿🇦 Bellville, South Africa

North-West University; 🇿🇦 Potchefstroom, South Africa

Pamoja Tunaweza Women Center; 🇹🇿 Moshi, Tanzania

State Key Laboratory of Cardiovascular Disease, Fuwai Hospital; 🇨🇳 Beijing, China

Universidad de La Frontera; 🇨🇱 Temuco, Chile

Post Graduate Institute of Medical Education and Research (PGIMER); 🇮🇳 Chandigarh, India

Estudios Clinicos Latinoamerica ECLA; 🇦🇷 Rosario, Santa Fe, Argentina

Health Action by People; 🇮🇳 Thiruvananthapuram, Kerala, India

University of Philippines, Section of Adult Medicine & Medical Research Unit; 🇵🇭 Manila, Philippines

Research Institute for Complex Issues of Cardiovascular Diseases; 🇷🇺 Kemerovo, Russian Federation

Istanbul Medeniyet University; 🇹🇷 İstanbul, Turkey

University of Zimbabwe College of Health Sciences; 🇿🇼 Harare, Zimbabwe

Madras Diabetes Research Foundation; 🇮🇳 Chennai, Tamil Nadu, India

Universidad Peruana Cayetano Heredia; 🇵🇪 Lima, Peru

Dubai Medical University; 🇦🇪 Dubai, United Arab Emirates

Birzeit University, Birzeit; 🇵🇸 Ramallah, Palestinian Territory, occupied

University of Ottawa; 🇨🇦 Ottawa, Ontario, Canada

Eternal Heart Care Centre and Research Institute; 🇮🇳 Jaipur, Rajasthan, India